TNFRSF1A

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD120a (cluste of differentiation 120a), also known as TNFR1 / TNFRSF1A, is a member of CD family, tumor necrosis factor receptor superfamily. CD120a is one of the most primary receptors for the tumor necrosis factor-alpha. It has been shown to be localized to both plasma membrane lipid rafts and the trans golgi complex with the help of the death domain (DD). CD120a can activate the transcription factor NF-κB, mediate apoptosis, and regulate inflammation processes.

TNFRSF1A Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>TNFR1/CD120a/TNFRSF1A

Immunology>>Cytokine & Receptor>>TNF Superfamily>>TNFR1/CD120a/TNFRSF1A

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>TNFR1/CD120a/TNFRSF1A

TNFRSF1A Alternative Names

TNFR1, TNFRSF1A, CD120a, FPF, MGC19588, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR55, TNFR60, p55, p55-R, p60

Summaries for TNFRSF1A

Entrez Gene summary for TNFRSF1A:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

OMIM - description for TNFRSF1A:

Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome

Wikipedia summary for TNFRSF1A:

Tumor necrosis factor receptor superfamily member 1A is a protein that in humans is encoded by the TNFRSF1A gene.[1][2] The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome [3]. Impaired receptor clearance is thought to be a mechanism of the disease.[4]. Mutations in the TNFRSF1A gene is associated with elevated risk of multiple sclerosis [5]. Serum levels of TNFRSF1A are elevated in severe mental disorders[6]. High serum levels is also associated with cognitive impairment and dementia

Human TNFRSF1A Protein General Information

 

• Protein names: Tumor necrosis factor receptor type 1-associated DEATH domain protein, Short name=TNFR1-associated DEATH domain protein
• Sequence length: 312 AA.
• Domain: Requires the intact DEATH domain to associate with TNFRSF1A/TNFR1.
• Sequence similarities: Contains 1 death domain.
• Subunit structure: Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP.
• Subcellular location: Cytoplasm › cytoskeleton

General information above from UniProt

Function for TNFRSF1A Protein

UniProtKB:

Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

Genatlas:

• TNFRSF1A is involved at least in two independent pathways
• acidic sphingomyelinase controlling expression of multiple TNF-responsive genes, including the apoptotic pathway
• neutral sphingomyelinase critical for the inflammatory and proliferative responses induced by TNF
• TNFRSF1A plays a key role in the initiation of inflammation, host defense, apoptosis, and cell survival through its ability to activate NFKB, mitogen-activated protein kinases, caspase-8, and other signaling responses
• TNFRSF1A potential role as a positive T-cell costimulatory molecule that is important for timely T-cell activation and effector cytokine production and the development of primary immune responses
• important for the development of secondary lymphoid organs during embryonic life, and is required for the formation of splenic compartments during adult, but not embryonic life

Homology for human TNFRSF1A

• homolog to murine Tnfrsf1a (73 pc)

Phenotype Information for TNFRSF1A

• Gene/Locus: TNFRSF1A, TNFR1, TNFAR, FPF
• Phenotype: Periodic fever, familial

Phenotype Information for TNFRSF1A from OMIM (Online Mendelian Inheritance in Man)

Drugs for TNFRSF1A

Target	Drug Name	Disease	Drug Status
TNFRSF1A	Pentoxifylline	Intermittent claudication	Approved
TNFRSF1A	Etanercept	Rheumatoid arthritis	Approved
TNFRSF1A	Infliximab	Psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis and ulcerative colitis	Approved
TNFRSF1A	Infliximab	Asthma	Phase III
TNFRSF1A	Adalimumab	Rheumatoid arthritis	Approved
TNFRSF1A	Thalidomide	Multiple myeloma	Approved

Drugs for TNFRSF1A from TTD (Therapeutic Targets Database)

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