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>Human Cell Expressed
>Cynomolgus / Rhesus TNFRSF17 / BCMA Protein (Fc Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Tumor necrosis factor receptor superfamily, member 17 Protein Datasheet
TNFRSF17 Protein Price Inquiry ( Available Sizes )
TNFRSF17 Protein Product Information
|Protein Construction:||A DNA sequence encoding the cynomolgus TNFRSF17 [(Identical to the rhesus TNFRSF17 (F7FFA0)] (Met1-Ala53) was expressed with the Fc region of human IgG1 at the C-terminus.|
|Expression Host:||Human Cells|
TNFRSF17 Protein QC Testing
|Purity:||> 95 % as determined by SDS-PAGE||SDS-PAGE:
|Measured by its binding ability in a functional ELISA.
Immobilized human BAFF (Cat:10056-HNCH) at 10 μg/ml (100 μl/well) can bind Cynomolgus TNFRSF17-Fc, The EC50 of Cynomolgus TNFRSF17-Fc is 0.03-0.07 μg/mL.
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Met|
The recombinant cynomolgus TNFRSF17 is a disulfide-linked homodimer. The reduced monomer comprises 294 amino acids and has a calculated molecular mass of 33 KDa.The apparent molecular mass of the protein is approximately 38-42 KDa respectively in SDS-PAGE.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
TNFRSF17 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
TNFRSF17 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|TNFRSF17/BCMA||Human||TNFRSF17/BCMA/Fc Protein, Recombinant||10620-H03H|
|TNFRSF17/BCMA||Mouse||TNFRSF17/BCMA/Fc Protein, Recombinant||50076-M01H|
|TNFRSF17/BCMA||Mouse||TNFRSF17/BCMA Protein, Recombinant||50076-M03H|
|TNFRSF17/BCMA||Rat||TNFRSF17 Protein, Recombinant||80156-R01H|
|TNFRSF17/BCMA||Cynomolgus||TNFRSF17 Protein, Recombinant||90103-C02H|
TNFRSF17 Protein Description
The tumor necrosis factor (TNF) receptor superfamily are a group of cell surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. Human tumor necrosis factor receptor superfamily member 17, also known as B-cell maturation protein, TNFRSF17, BCMA, and CD269, is a single-pass type I II membrane protein which contains one TNFR-Cys repeat. TNFRSF17 is a member of the TNF receptor superfamily, and is preferentially expressed in mature B lymphocytes. It binds specifically to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), as well as various TNFR-associated factor (TRAF) family members including TRAF1, TRAF2 and TRAF3 adaptor proteins, and thus transduces signals for cell survival and proliferation. Lacking a "death domain", overexpression of TNFRSF17 activates NF-kappa B and c-Jun N-terminal kinase. TNFRSF17 is also found in a perinulear Golgi-like structure.
- Hatzoglou A. et al., 2000, J Immunol. 165 (3): 1322-1330.
- Zhou T. et al., 2002, Immunol Res. 26 (1-3): 323-336.
- Liu Y. et al., 2003, Nature. 423: 49-56.
- Hymowitz SG. et al., 2005, J Biol Chem. 280: 7218-7227.
|Tumor Necrosis Factor (TNF) Family & Receptor|