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Product Catalog
> TNFRSF17 / BCMA Protein TNFRSF17 / BCMA Protein
Tumor Necrosis Factor Receptor Superfamily, member 17 / B cell Maturation Antigen
TNFRSF17 / BCMA Products
TNFRSF17 / BCMA Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| TNFRSF17/BCMA | Human | TNFRSF17/BCMA/Fc Protein, Recombinant |
10620-H03H |
| TNFRSF17/BCMA | Mouse | TNFRSF17/BCMA/Fc Protein, Recombinant | 50076-M01H |
| TNFRSF17/BCMA | Mouse | TNFRSF17/BCMA Protein, Recombinant | 50076-M03H |
TNFRSF17 / BCMA cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| TNFRSF17/BCMA | Human | Homo sapiens TNFRSF17/BCMA cDNA Clone(NM_001192.2) | HG10620-M |
| TNFRSF17/BCMA | Mouse | Mus musculus TNFRSF17/BCMA cDNA Clone | MG50076-M |
| TNFRSF17/BCMA | Rat | Rat TNFRSF17/BCMA cDNA Clone | RG80156-G |
| TNFRSF17/BCMA | Cynomolgus | Cynomolgus monkey TNFRSF17 cDNA Clone / ORF Clone | KG90103-G |
TNFRSF17 / BCMA Related Areas
Immunology>>Cytokine & Receptor>>TNF Superfamily>>TNFRSF17/BCMA
Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>TNFRSF17/BCMA/CD269
TNFRSF17 / BCMA Alternative Names
TNFRSF17, BCMA, BCM, CD269 [Homo sapiens]
TNFRSF17, BCMA, BCM, Tnfrsf13, Tnfrsf13a [Mus musculus]
TNFRSF17 / BCMA Related Products
Protein Products
Antibody Products
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! |
| Human TNFRSF1B/TNFR2/CD120b |
WB, ELISA | Rabbit Polyclonal Antibody |
| Human TNFRSF1B/TNFR2/CD120b |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
| Human TNFRSF5/CD40 |
WB, ELISA | Rabbit Polyclonal Antibody |
| Human TNFRSF5/CD40 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
| Human TNFRSF10B/CD262/ TRAILR2 |
WB, ELISA | Rabbit Polyclonal Antibody |
| Human TNFRSF10B/CD262/ TRAILR2 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
cDNA Clone Products
TNFRSF17 / BCMA Background
Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.
TNFRSF17 / BCMA Related Studies
- Novak AJ, et al. (2004) Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival. Blood. 103 (2): 689–94.
- O'Connor BP, et al. (2004) BCMA is essential for the survival of long-lived bone marrow plasma cells. J Exp Med. 199(1): 91-8.
- Moser K, et al. (2006) Stromal niches, plasma cell differentiation and survival. Curr Opin Immunol. 18(3): 265-70.
