Anti-RANK Antibody

Cat: 80160-RP01
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Anti-RANK Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-RANK Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Rat
Specificity
Rat RANK
Immunogen
Recombinant Rat TNFRSF11A protein (Catalog#80160-R08H)
Preparation
Produced in rabbits immunized with purified, recombinant Rat TNFRSF11A (rR TNFRSF11A; Catalog#80160-R08H; XP_573424.2; Met1-Pro213). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-RANK Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-RANK Antibody Alternative Names
Anti-TNFRSF11A Antibody
RANK Background Information

TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. Defects in TNFRSF11A can cause familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.

Full Name
tumor necrosis factor receptor superfamily member 11a
References
  • Darnay B G, et al. (1998) Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem. 273(32):20551-5.
  • Darnay B G, et al. (1999) Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. J Biol Chem. 274(12):7724-31.
  • Galibert L, et al. (1998) The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J Biol Chem. 273(51):34120-7.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-RANK Antibody Rabbit Polyclonal ELISA 80160-T16
    Anti-RANK Antibody Rabbit Monoclonal ELISA 80160-R044
    Anti-RANK Antibody Rabbit Monoclonal ELISA 16078-R107
    Anti-RANK Antibody Rabbit Polyclonal ELISA 16078-T16
    Anti-RANK Antibody Rabbit Polyclonal WB,ICC/IF,IF 100431-T34
    Anti-RANK Antibody Rabbit Polyclonal ELISA 16078-RP01
    Anti-RANK Antibody Rabbit Polyclonal WB,ELISA 16078-T48
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