|Datasheet||Specific References||Reviews||Related Products||Protocols|
|ORF Clone of Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain DNA.|
|Identical with XM_001097022.2 [ Macaca mulatta (Rhesus monkey) ]: 231 C/A, 592 C/A, 803-804 TG/CA resulting in the amino acid Ser substitution by Arg, Pro substitution by Thr, Met substitution by Thr and 27 G/A,132 C/G not causing the amino acid variation. Please check the sequence information before order.|
|Whatman FTA elute card (Cat: WB120410) contains 5-10 μg of plasmid.|
|The Whatman FTA elute card can be stored at room temperature for three months under dry condition.|
The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.
The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.
|Cynomolgus monkey TNFRSF10D / TRAILR4 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged||CG90100-G-F|
|Cynomolgus monkey TNFRSF10D / TRAILR4 Gene cDNA Clone (full-length ORF Clone), expression ready, His-tagged||CG90100-G-H|
|Cynomolgus monkey TNFRSF10D / TRAILR4 Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-tagged||CG90100-G-M|
|Cynomolgus monkey TNFRSF10D / TRAILR4 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged||CG90100-G-N|
|Cynomolgus monkey TNFRSF10D / TRAILR4 Gene cDNA Clone (full-length ORF Clone), expression ready, HA-tagged||CG90100-G-Y|
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Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), also known as TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4), CD264, and Decoy receptor 2, is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. TRAIL R4/CD264/TNFRSF10D is widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. TRAIL R4/CD264/TNFRSF10D is also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. The signaling capacity of TRAIL R4 is similar to that of TRAIL R1 and TRAIL R2 with respect to NF-κB activation, but differs in its inability to induce apoptosis. TRAIL R4 retains a C-terminal element containing one third of a consensus death domain motif. Transient overexpression of TRAIL R4 in cells normally sensitive to TRAIL-mediated killing confers complete protection, suggesting that one function of TRAIL R4 may be inhibition of TRAIL cytotoxicity.