TNFR2 / CD120b / TNFRSF1B Antibody (Cytokine)

TNFR2 / CD120b / TNFRSF1B Antibody Datasheet

TNFR2 / CD120b / TNFRSF1B Antibody Product Information

• Immunogen: Recombinant Mouse TNFR2 / CD120b / TNFRSF1B protein (Catalog#50128-M08H)
• Antibody Type: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
• Ig Type: Rabbit IgG
• Formulation: 0.2 μm filtered solution in PBS with 5% trehalose
• Preparation: Produced in rabbits immunized with purified, recombinant Mouse TNFR2 / CD120b / TNFRSF1B (rM TNFR2 / CD120b / TNFRSF1B; Catalog#50128-M08H; NP_033491.2; Met 1-Gly 258). Total IgG was purified by Protein A affinity chromatography.

TNFR2 / CD120b / TNFRSF1B Antibody Usage Guide

• Specificity: Mouse TNFR2 / CD120b / TNFRSF1B
• Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse TNFRSF1B in WB.
• Direct ELISA: This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse TNFRSF1B. The detection limit for Mouse TNFRSF1B is approximately 0.00245 ng/well.
• Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
  Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

TNFR2 / CD120b / TNFRSF1B Antibody Background

TNFRII, also known as TNFRSF1B, is a member to the TNFR (tumor necrosis factor receptor) superfamily characterized by cysteine-rich extracellular domains. TNFRII is expressed in fetal brain. The protein is produced naturally as a soluble form (sTNFRII). The soluble receptor inhibits TNFα action by competing with cell surface receptors in binding TNFα, thereby blocking its biologic effects. TNFRII is strongly expressed at the cartilage-pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). Further, high plasma levels of sTNFRII were significantly associated with increased incidence of coronary heart disease, independent of established cardiovascular risk factors, and seems to be useful for monitoring the inflammatory activity of sarcoidosis.

References

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4. Ziegenhagen,M W. et al., 2000, Journal of Internal Medicine. 248 (1): 33-41.
5. Iris Shai. et al., 2005, Diabetes Care. 6: 1376-82.