0 products, total $0.+86-400-890-9989      Login |  Register 中文한국어

Browse By Molecule:

Your Position: Home > TNFR2 Protein & Antibody (TNFRSF1B, CD120b)

TNFR2 Protein & Antibody (TNFRSF1B, CD120b)

Tumor Necrosis Factor Receptor Superfamily, member 1B (Cluster of Differentiation 120b)

TNFR2 Products

TNFR2 Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
TNFR2/CD120b Human TNFR2/CD120b/Fc Protein, Recombinant 10417-H03H
TNFR2/CD120b Human TNFR2/CD120b Protein, Recombinant 10417-H08H
TNFR2/CD120b Mouse TNFR2/CD120b/Fc Protein, Recombinant 50128-M02H
TNFR2/CD120b Mouse TNFR2/CD120b Protein, Recombinant 50128-M08H
TNFR2 Cynomolgus TNFRSF1B Protein, Recombinant 90102-C08H

 10417-H03H:  ED50 = 4.5 ng / ml. Measured by its ability to inhibit the TNF-α mediated cytotoxicity in the L-929 mouse fibrosarcoma cells in the presence of 0.25 ng/mL recombinant human TNF-α and the metabolic inhibitor actinomycin D.

 10417-H08H:  ED50 = 0.68 μg / mL .  Measured by its ability to inhibit the TNF-α mediated cytotoxicity in the L-929 mouse fibrosarcoma cells in the presence of 0.25 ng/mL recombinant human TNF-α and the metabolic inhibitor actinomycin D.

TNFR2 Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
TNFR2/CD120b
WB, ELISA Rabbit Monoclonal Antibody 10417-R006
Human
TNFR2/CD120b
WB, ELISA Rabbit Polyclonal Antibody 10417-RP01
Human
TNFR2/CD120b
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 10417-RP02
Mouse
TNFR2/CD120b
WB, ELISA TNFR2 / CD120b / TNFRSF1B Antibody 50128-RP01
Mouse
TNFR2/CD120b
WB, ELISA TNFR2 / CD120b / TNFRSF1B Antibody (Antigen Affinity Purified) 50128-RP02

TNFR2 cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
TNFR2/CD120b Human Homo sapiens TNFR2/CD120b cDNA Clone(NM_001066.2) HG10417-M
TNFR2/CD120b Mouse Mus musculus TNFR2/CD120b cDNA Clone MG50128-M
TNFR2 Cynomolgus Cynomolgus monkey TNFRSF1B cDNA Clone / ORF Clone CG90102-G

TNFR2 Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>TNFR2/CD120b

Immunology>>Cytokine & Receptor>>TNF Superfamily>>TNFR2/CD120b

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>TNFR2/CD120b

TNFR2 Alternative Names

TNFR2, TNFRSF1B, CD120b, TNF-R2, TNF-RII, TNFR-II, p75 TNF receptor, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR [Homo sapiens]

TNF-R2, Tnfrsf1b, CD120b, TNF-RII, TNFR-II, p75 TNFR, RP23-157J11.1, TNF-R-II, TNF-R75, TNF-alphaR2, TNFBR, TNFR80, TNFRII, TNFalpha-R2, Tnfr-1, Tnfr2, p75 [Mus musculus]

TNFR2 Background

Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

TNFR2 Related Studies

  1. Komata T, et al. (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens. 53(6): 527-33.
  2. Tsuchiya N, et al. (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun. 2(6): 317-22.
  3. Guo G, et al. (1999) Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 277(5): 766-72.

TNF Superfamily Ligands

  • EDA-A1 / Ectodysplasin-A1*
  • TNFSF6 / CD95L / CD178*
  • TNFSF12 / TWEAK*
  • TNFSF13 / CD256*
  • TNFSF3 / TNFC / lymphotoxin beta*
  • TNFSF4*
  • TNFSF15*

TNF Receptor Superfamily

  • TNFRSF3 / CD18 / LTBR*
  • TNFRSF10C / CD263 / TRAILR3*
  • TNFRSF18*
  • TNFRSF12A / FN14 / TWEAKR*
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
_×