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> TNFR2 Protein & Antibody (TNFRSF1B, CD120b) TNFR2 Protein & Antibody (TNFRSF1B, CD120b)
Tumor Necrosis Factor Receptor Superfamily, member 1B (Cluster of Differentiation 120b)
TNFR2 Products
TNFR2 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| TNFR2/CD120b | Human | TNFR2/CD120b/Fc Protein, Recombinant  |
10417-H03H |
| TNFR2/CD120b | Human | TNFR2/CD120b Protein, Recombinant |
10417-H08H |
| TNFR2/CD120b | Mouse | TNFR2/CD120b/Fc Protein, Recombinant | 50128-M02H |
| TNFR2/CD120b | Mouse | TNFR2/CD120b Protein, Recombinant | 50128-M08H |
| TNFR2 | Cynomolgus | TNFRSF1B Protein, Recombinant | 90102-C08H |
TNFR2 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human TNFR2/CD120b |
WB, ELISA | Rabbit Monoclonal Antibody | 10417-R006 |
| Human TNFR2/CD120b |
WB, ELISA | Rabbit Polyclonal Antibody | 10417-RP01 |
| Human TNFR2/CD120b |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 10417-RP02 |
| Mouse TNFR2/CD120b |
WB, ELISA | TNFR2 / CD120b / TNFRSF1B Antibody | 50128-RP01 |
| Mouse TNFR2/CD120b |
WB, ELISA | TNFR2 / CD120b / TNFRSF1B Antibody (Antigen Affinity Purified) | 50128-RP02 |
TNFR2 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| TNFR2/CD120b | Human | Homo sapiens TNFR2/CD120b cDNA Clone(NM_001066.2) | HG10417-M |
| TNFR2/CD120b | Mouse | Mus musculus TNFR2/CD120b cDNA Clone | MG50128-M |
| TNFR2 | Cynomolgus | Cynomolgus monkey TNFRSF1B cDNA Clone / ORF Clone | CG90102-G |
TNFR2 Related Areas
Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>TNFR2/CD120b
Immunology>>Cytokine & Receptor>>TNF Superfamily>>TNFR2/CD120b
Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>TNFR2/CD120b
TNFR2 Alternative Names
TNFR2, TNFRSF1B, CD120b, TNF-R2, TNF-RII, TNFR-II, p75 TNF receptor, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR [Homo sapiens]
TNF-R2, Tnfrsf1b, CD120b, TNF-RII, TNFR-II, p75 TNFR, RP23-157J11.1, TNF-R-II, TNF-R75, TNF-alphaR2, TNFBR, TNFR80, TNFRII, TNFalpha-R2, Tnfr-1, Tnfr2, p75 [Mus musculus]
TNFR2 Background
Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
TNFR2 Related Studies
- Komata T, et al. (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens. 53(6): 527-33.
- Tsuchiya N, et al. (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun. 2(6): 317-22.
- Guo G, et al. (1999) Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 277(5): 766-72.
TNF Superfamily Ligands
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TNF Receptor Superfamily
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