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TNFR2 / CD120b / TNFRSF1B Antibody, Rabbit MAb

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Human TNFR2/TNFRSF1B Antibody Product Information
Immunogen:Recombinant Human TNFR2 protein (Catalog#10417-H08H)
Clone ID:6
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human TNFRSF1B / CD120b (rh TNFRSF1B; Catalog#10417-H08H; Met 1-Asp 257; NP_001057.1).
Human TNFR2/TNFRSF1B Antibody Usage Guide
Specificity:Human TNFRSF1B / TNFR2 / CD120b
No cross-reactivity in ELISA with
Human TNFRSF9 / CD137
Human TNFRSF7 / CD27
Human TNFRSF8 / CD30
Human TNFRSF5 / CD40
Human TNFRSF6 / CD95 / Fas
Human TNFRSF14 / HVEM
Human TNFRSF21 / DR6
Mouse TNFRSF7 / CD27
Mouse TNFRSF14 / HVEM
Application:ELISA

ELISA: 0.5-1 μg/mL

This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human TNFRII. The detection limit for TNFRII is 0.00245 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
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                      TNFR2/TNFRSF1B/CD120b Background

                      Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

                      Human TNFR2/TNFRSF1B/CD120b References
                    • Komata T, et al. (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens. 53(6): 527-33.
                    • Tsuchiya N, et al. (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun. 2(6): 317-22.
                    • Guo G, et al. (1999) Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 277(5): 766-72.
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                      Size / Price
                      Catalog: 10417-R006-50
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                      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"