Anti-TNFR2 Antibody

Cat: 10417-RP02
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All TNFR2 Reagents
Anti-TNFR2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-TNFR2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human TNFR2
Immunogen
Recombinant Human TNFR2 protein (Catalog#10417-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human TNFRSF1B / CD120b (rh TNFRSF1B; Catalog#10417-H08H; NP_001057.1; Met 1-Asp 257). TNFRSF1B specific IgG was purified by human TNFRSF1B affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TNFR2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TNFR2 Antibody Alternative Names
Anti-CD120b Antibody;Anti-p75 Antibody;Anti-p75TNFR Antibody;Anti-TBPII Antibody;Anti-TNF-R-II Antibody;Anti-TNF-R75 Antibody;Anti-TNFBR Antibody;Anti-TNFR1B Antibody;Anti-TNFR2 Antibody;Anti-TNFR80 Antibody
TNFR2 Background Information

Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
tumor necrosis factor receptor superfamily, member 1b
References
  • Komata T, et al. (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens. 53(6): 527-33.
  • Tsuchiya N, et al. (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun. 2(6): 317-22.
  • Guo G, et al. (1999) Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 277(5): 766-72.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TNFR2 Antibody Rabbit Monoclonal ELISA 90102-R001
    Anti-TNFR2 Antibody Mouse Monoclonal ELISA 90102-MM01
    Anti-TNFR2 Antibody Rabbit Polyclonal ELISA 90102-T16
    Anti-TNFR2 Antibody Rabbit Monoclonal ELISA 50128-R101
    Anti-TNFR2 Antibody Rabbit Monoclonal FCM 50128-R112
    Anti-TNFR2 Antibody Rabbit Polyclonal WB,ELISA,IP 50128-RP02
    Anti-TNFR2 Antibody Rabbit Monoclonal ELISA(Det) 50128-R340
    Anti-TNFR2 Antibody (APC) Rabbit Monoclonal FCM 50128-R112-A
    Anti-TNFR2 Antibody Rabbit Polyclonal ELISA 50128-RP01
    TNFR2/TNFRSF1B/CD120b Neutralizing Antibody Rabbit Monoclonal Neutralization 50128-RN204
    Anti-TNFR2 Antibody Rabbit Monoclonal ELISA(Cap) 50128-R204
    Anti-TNFR2 Antibody (PE) Rabbit Monoclonal FCM 50128-R112-P
    Anti-TNFR2 Antibody Rabbit Polyclonal ELISA 10417-RP01
    Anti-TNFR2 Antibody Mouse Monoclonal ELISA 10417-MM05
    TNFR2 / CD120b / TNFRSF1B Neutralizing Antibody Rabbit Monoclonal Neutralization 10417-R00N6
    Anti-TNFR2 Antibody Rabbit Monoclonal ELISA 10417-R006
    Anti-TNFR2 Antibody Rabbit Monoclonal ELISA 10417-R003
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