TNF-beta / TNFSF1 / Lymphotoxin alpha Protein & Antibody

TNF superfamily, member 1

TNF-beta / TNFSF1 / Lymphotoxin alpha Products

TNF-beta / TNFSF1 / Lymphotoxin alpha Protein, Recombinant

Molecule	Species	Description	Cat. No
TNF-beta/TNFSF1/Lymphotoxin alpha	Human	TNF-beta/TNFSF1/Lymphotoxin alpha Protein, Recombinant, Native	10270-HNAE

  10270-HNAE: The ED₅₀ for this effect is typically 0.17 ng/ml. Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D.

TNF-beta / TNFSF1 / Lymphotoxin alpha Antibody

Molecule	Application	Description	Cat. No
Human TNF-beta/TNFSF1/Lymphotoxin alpha	WB, ELISA	TNF-beta / TNFSF1 / Lymphotoxin alpha Antibody	10270-MM02
Human TNF-beta/TNFSF1/Lymphotoxin alpha	WB, ELISA	TNF-beta / TNFSF1 / Lymphotoxin alpha Antibody (Antigen Affinity Purified)	10270-RP02

TNF-beta / TNFSF1 / Lymphotoxin alpha cDNA Clone

Molecule	Species	Description	Cat. No
TNF-beta/TNFSF1/Lymphotoxin alpha	Human	TNF-beta/TNFSF1/Lymphotoxin alpha cDNA Clone / ORF Clone	HG10270-M
TNF-beta/TNFSF1/Lymphotoxin alpha	Mouse	TNF-beta/TNFSF1/Lymphotoxin alpha cDNA Clone / ORF Clone	MG50682-M
TNF-beta/TNFSF1/Lymphotoxin alpha	Rat	TNF-beta/TNFSF1/Lymphotoxin alpha cDNA Clone / ORF Clone	RG80147-G
TNF-beta/TNFSF1/Lymphotoxin alpha	Cynomolgus	LTA cDNA Clone / ORF Clone	KG90086-G

TNF-beta / TNFSF1 / Lymphotoxin alpha Related Areas

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>TNF-beta/TNFSF1/Lymphotoxin alpha

Immunology>>Cytokine & Receptor>>TNF Superfamily>>TNF-beta/TNFSF1/Lymphotoxin alpha

TNF-beta / TNFSF1 / Lymphotoxin alpha Alternative Names

TNF-beta, TNFSF1, Lymphotoxin alpha, LTA, DAMA-25N12.13-004, LT, TNFB [Homo sapiens]

TNF-beta, TNFSF1, Lymphotoxin alpha, Lta, LT, LT-[a], LT-alpha, LT[a], LTalpha, Ltx, MGC117668, TNF-beta, TNFSF1, Tnfb, Tnfsf1b, hlb382 [Mus musculus]

TNF-beta / TNFSF1 / Lymphotoxin alpha Background

Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1 and TNFB, is a secreted protein which belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is a highly inducible, secreted, and exists as homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRSF3 / LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells. TNF-beta/TNFSF1/Lymphotoxin alpha forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNF-beta/TNFSF1/Lymphotoxin alpha is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in TNF-beta/TNFSF1/Lymphotoxin alpha are a cause of susceptibility psoriatic arthritis which is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy.

TNF-beta / TNFSF1 / Lymphotoxin alpha Related Studies

1. Messer G, et al. (1991) Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. J Exp Med. 173(1): 209-19.
2. Banner DW, et al. (1993) Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell. 73(3): 431-45.
3. Picarella DE, et al. (1993) Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice. J Immunol. 150(9): 4136-50.