Anti-TNF beta Antibody (PE)

Cat: 10270-MM05-P

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Anti-TNF beta Antibody (PE) (Mouse Monoclonal antibody) General Information
Product name
Anti-TNF beta Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human TNF beta
No cross-reactivity in ELISA with Human TNFa Mouse TNFa Human TNFRI Human TNFRⅡ
Immunogen
Recombinant Human TNF-beta / TNFSF1 / Lymphotoxin alpha protein (Catalog#10270-HNAE)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TNF-beta / TNFSF1 / Lymphotoxin alpha (rh TNF-beta / TNFSF1 / Lymphotoxin alpha; Catalog#10270-HNAE; P01374; Leu35-Leu205) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Mouse IgG1 Clone #05
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-TNF beta Antibody (PE) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TNF beta Antibody (PE) (Mouse Monoclonal antibody) Images
Human TNF-beta/TNFSF1/Lymphotoxin alpha  Flow Cytometry (FC) 5001
Flow cytometric analysis of Human TNFβ expression in HUT78 cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with PE Mouse anti-Human TNFβ. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Anti-TNF beta Antibody (PE) Alternative Names
Anti-LT Antibody;Anti-TNFB Antibody;Anti-TNFSF1 Antibody
TNF beta Background Information

Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1 and TNFB, is a secreted protein which belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is a highly inducible, secreted, and exists as homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRSF3 / LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells. TNF-beta/TNFSF1/Lymphotoxin alpha forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNF-beta/TNFSF1/Lymphotoxin alpha is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in TNF-beta/TNFSF1/Lymphotoxin alpha are a cause of susceptibility psoriatic arthritis which is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy.

Full Name
lymphotoxin alpha
References
  • Messer G, et al. (1991) Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. J Exp Med. 173(1): 209-19.
  • Banner DW, et al. (1993) Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell. 73(3): 431-45.
  • Picarella DE, et al. (1993) Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice. J Immunol. 150(9): 4136-50.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TNF beta Antibody Rabbit Monoclonal ELISA(Det) 10270-R074
    Anti-TNF beta Antibody Rabbit Polyclonal ELISA 10270-T16
    Anti-TNF beta Antibody Mouse Monoclonal ELISA,ELISA(Cap) 10270-MM02
    Anti-TNF beta Antibody Rabbit Polyclonal ELISA 10270-RP02
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