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TNF-beta / TNFSF1 / Lymphotoxin alpha Antibody (FITC), Mouse MAb

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Human LTA Antibody Product Information
Immunogen:Recombinant Human TNF-beta / TNFSF1 / Lymphotoxin alpha protein (Catalog#10270-HNAE)
Clone ID:05
Ig Type:Mouse IgG1
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TNF-beta / TNFSF1 / Lymphotoxin alpha (rh TNF-beta / TNFSF1 / Lymphotoxin alpha; Catalog#10270-HNAE; P01374; Leu35-Leu205) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Human LTA Antibody Usage Guide
Specificity:Human TNF-beta / TNFSF1 / Lymphotoxin alpha
No cross-reactivity in ELISA with
Human TNFa
Mouse TNFa
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Human LTA Antibody FC Application Image
TNF-beta / TNFSF1 / Lymphotoxin alpha Antibody (FITC), Mouse MAb, Flow cytometric
[Click to enlarge image]
Flow cytometric analysis of Human TNFβ expression in HUT78 cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with FITC Mouse anti-Human TNFβ. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Other LTA Antibody Products
TNF-beta/TNFSF1/Lymphotoxin alpha  Background

Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1 and TNFB, is a secreted protein which belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is a highly inducible, secreted, and exists as homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRSF3 / LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells. TNF-beta/TNFSF1/Lymphotoxin alpha forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNF-beta/TNFSF1/Lymphotoxin alpha is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in TNF-beta/TNFSF1/Lymphotoxin alpha are a cause of susceptibility psoriatic arthritis which is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy.

Human TNF-beta/TNFSF1/Lymphotoxin alpha  References
  • Messer G, et al. (1991) Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. J Exp Med. 173(1): 209-19.
  • Banner DW, et al. (1993) Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell. 73(3): 431-45.
  • Picarella DE, et al. (1993) Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice. J Immunol. 150(9): 4136-50.
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