Text Size:AAA

TNF-alpha/TNFA Protein, Antibody, ELISA Kit, cDNA Clone

Mouse TNF-alpha/TNFA Protein

Description: Active
Expression host: E. coli
  • Slide 1
50349-MNAE-5
50349-MNAE-100
50349-MNAE-50
5 µg / $38
100 µg / $290
50 µg / $170
Add to Cart

Rat TNF-alpha/TNFA Protein

Description: Active
Expression host: E. coli
  • Slide 1
80045-RNAE-10
80045-RNAE-20
10 µg / $70
20 µg / $110
Add to Cart

Canine TNF-alpha/TNFA Protein

Description: Active
Expression host: E. coli
  • Slide 1
70003-DNAE-5
70003-DNAE-20
70003-DNAE-50
5 µg / $38
20 µg / $140
50 µg / $290
Add to Cart

Cynomolgus TNF-alpha/TNFA Protein

Expression host: E. coli
  • Slide 1
90330-CNAE-50
90330-CNAE-20
50 µg / $170
20 µg / $100
Add to Cart
Description: Active
Expression host: E. coli
  • Slide 1
  • Slide 1
  • Slide 1
90018-CNAE-20
90018-CNAE-50
20 µg / $90
50 µg / $160
Add to Cart

Human TNF-alpha/TNFA Protein

Description: Active
Expression host: E. coli
  • Slide 1
10602-HNAE-50
10602-HNAE-100
10602-HNAE-5
50 µg / $130
100 µg / $190
5 µg / $38
Add to Cart

Ferret TNF-alpha/TNFA Protein

Description: Active
Expression host: E. coli
  • Slide 1
60002-FNAE-10
60002-FNAE-20
10 µg / $200
20 µg / $350
Add to Cart

TNF-alpha/TNFA Related Areas

TNF-alpha/TNFA Related Pathways

TNF-alpha/TNFA Related Product

TNF-alpha/TNFA Summary & Protein Information

TNF-alpha/TNFA Related Information

TNF-alpha/TNFA Background

Gene Summary: Tumor necrosis factor (TNF) is a multifunctional proinflammatory cytokine secreted predominantly by monocytes/macrophages that has effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. TNF was originally identified in mouse serum after injection with Mycobacterium bovis strain bacillus Calmette-Guerin (BCG) and endotoxin. Serum from such animals was cytotoxic or cytostatic to a number of mouse and human transformed cell lines and produced hemorrhagic necrosis and in some instances complete regression of certain transplanted tumors in mice
General information above from NCBI
Subunit structure: Homotrimer. Interacts with SPPL2B.
Subcellular location: Cell membrane; Single-pass type II membrane protein.
Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein.
Tumor necrosis factor, soluble form: Secreted.
C-domain 1: Secreted.
C-domain 2: Secreted.
Post-translational: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C- domain 2 secreted into the extracellular space.
The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
O-glycosylated; glycans contain galactose, N- acetylgalactosamine and N-acetylneuraminic acid.
Involvement in disease: Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Sequence similarity: Belongs to the tumor necrosis factor family.
General information above from UniProt

Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.

TNF-alpha Protein & Antibody

TNF-alpha/TNFA Alternative Name

TNF-alpha/TNFA Related Studies

  • Hector J, et al. (2007) TNF-alpha alters visfatin and adiponectin levels in human fat. Horm Metab Res. 39(4): 250-5.
  • Berthold-Losleben M, et al. (2008) The TNF-alpha System: Functional Aspects in Depression, Narcolepsy and Psychopharmacology. Curr Neuropharmacol. 6(3): 193-202.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"