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Tumor Necrosis Factor-alpha (TNF-alpha) Protein, Antibody, Gene & ELISA Kit

  • TNF-alpha Protein
  • TNF-alpha Antibody
  • TNF-alpha cDNA
  • TNF-alpha ELISA Kit

TNF-alpha Protein (Tumor Necrosis Factor Alpha Protein)

Human TNF-alpha Protein

Human TNF-alpha Protein (active) (10602-HNAE)   Activity assay
 
Tag: untagged
Expression host: E. coli
Price/Size: $190 / 100µgorder   SDS-PAGE

Mouse TNF-alpha Protein

Mouse TNF-alpha Protein (active) (50349-MNAE)   Activity assay
 
Tag: untagged
Expression host: E. coli
Price/Size: $460 / 200µgorder   SDS-PAGE

Rat TNF-alpha Protein

Rat TNF-alpha Protein (active) (80045-RNAE)   Activity assay
 
Tag: untagged
Expression host: E. coli
Price/Size: $110 / 20µgorder   SDS-PAGE

Cynomolgus TNF-alpha Protein

Cynomolgus TNF-alpha Protein (active) (90018-CNAE)   Activity assay
 
Tag: untagged
Expression host: E. coli
Price/Size: $160 / 50µgorder   SDS-PAGE

Canine TNF-alpha Protein

Canine TNF-alpha Protein (active) (70003-DNAE)   Activity assay
 
Tag: untagged
Expression host: E. coli
Price/Size: $260 / 50µgorder   SDS-PAGE

Ferret TNF-alpha Protein

Ferret TNF-alpha Protein (active) (60002-FNAE)   Activity assay
 
Tag: his
Expression host: E. coli
Price/Size: $350 / 20µgorder   SDS-PAGE

TNF-alpha Antibody (Tumor Necrosis Factor Alpha Antibody)

Anti Human TNF-alpha Antibody

Anti Human TNF-alpha Antibody (10602-MM01)   Flow cytometry analysis
 
Host & Clone: Mouse mAb
Application: WB, ELISA, FCM
Price/Size: $230 / 100µgorder   FCM
 
Anti Human TNF-alpha Antibody (10602-R211)    
 
Host & Clone: Rabbit mAb
Application: WB, ELISA
Price/Size: $290 / 100µgorder    
 
Anti Human TNF-alpha Antibody (FITC) (10602-MM01-F)   Flow cytometry analysis
 
Host & Clone: Mouse mAb
Application: FCM
Price/Size: $200 / 100Testsorder   FCM
 
Anti Human TNF-alpha Antibody (FITC) (10602-R101-F)   Flow cytometry analysis
 
Host & Clone: Mouse mAb
Application: FCM
Price/Size: $200 / 100Testsorder   FCM
 
Anti Human TNF-alpha Antibody (10602-RP03)    
 
Host & Clone: Rabbit pAb
Application: WB, ELISA
Price/Size: $230 / 200µgorder    

Anti Mouse TNF-alpha Antibody

Anti Mouse TNF-alpha Antibody (50349-RP01)    
 
Host & Clone: Rabbit pAb
Application: WB, ELISA
Price/Size: $230 / 200µgorder    
 
Anti Mouse TNF-alpha Antibody (50349-RP02)    
 
Host & Clone: Rabbit pAb
Application: WB, ELISA
Price/Size: $290 / 100µgorder    
 
Anti Mouse TNF-alpha Antibody (50349-R009)    
 
Host & Clone: Rabbit mAb
Application: WB, ELISA
Price/Size: $290 / 100µgorder    

Anti Rat TNF-alpha Antibody

Anti Rat TNF-alpha Antibody (80045-RP02)    
 
Host & Clone: Rabbit pAb
Application: WB, ELISA
Price/Size: $290 / 100µgorder    

Anti Canine TNF-alpha Antibody

Anti Canine TNF-alpha Antibody (70003-R001)    
 
Host & Clone: Rabbit mAb
Application: WB, ELISA
Price/Size: $290 / 100µgorder    
 
Anti Canine TNF-alpha Antibody (70003-RP01)    
 
Host & Clone: Rabbit pAb
Application: WB, ELISA
Price/Size: $230 / 200µgorder    
 
Anti Canine TNF-alpha Antibody (70003-RP02)    
 
Host & Clone: Rabbit pAb
Application: WB, ELISA
Price/Size: $290 / 100µgorder    
 
Anti Canine TNF-alpha Antibody (70003-MM04)    
 
Host & Clone: Mouse mAb
Application: WB, ELISA
Price/Size: $230 / 100µgorder    

Anti Ferret TNF-alpha Antibody

Anti Ferret TNF-alpha Antibody (60002-MM11)    
 
Host & Clone: Mouse mAb
Application: WB, ELISA
Price/Size: $230 / 100µgorder    

TNF-alpha cDNA Clone (Tumor Necrosis Factor Alpha cDNA Clone)

Human TNF-alpha cDNA Clone

Human TNF-alpha ORF Expression Clone, untagged (HG10602-M-N)
 
cDNA size: 702bp order
Expression Vector: pCMV / hygro
Price: $295
 
Human TNFα Gene cDNA Clone / ORF Clone (HG10602-M)
 
cDNA size: 702bp order
Price (Cloning Vector): $95 (pMD18-T Simple Vector)
Price (Expression Vector): $295  (pCMV / hygro)
$295 (pCMV / hygro - HA)
$295 (pCMV / hygro - His)
$295 (pCMV / hygro - Myc)
$295 (pCMV / hygro - FLAG)
 
Human TNFA ORF Expression Clone, Myc-tagged (HG10602-M-M)
 
cDNA size: 702bp order
Expression Vector: pCMV / hygro-Myc
Price: $295

Mouse TNF-alpha cDNA Clone

Mouse TNFα Gene cDNA Clone / ORF Clone (MG50349-M)
 
cDNA size: 708bp order
Price (Cloning Vector): $95 (pMD18-T Simple Vector)
Price (Expression Vector): $295  (pCMV / hygro)
$295 (pCMV / hygro - HA)
$295 (pCMV / hygro - His)
$295 (pCMV / hygro - Myc)
$295 (pCMV / hygro - FLAG)

Rat TNF-alpha cDNA Clone

Rat TNFα Gene cDNA Clone / ORF Clone (RG80045-M)
 
cDNA size: 708bp order
Price (Cloning Vector): $95 (pMD18-T Simple Vector)
Price (Expression Vector): $295  (pCMV / hygro)
$295 (pCMV / hygro - HA)
$295 (pCMV / hygro - His)
$295 (pCMV / hygro - Myc)
$295 (pCMV / hygro - FLAG)

Cynomolgus TNF-alpha cDNA Clone

Cynomolgus monkey TNFa Gene cDNA Clone / ORF Clone (CG90018-G )
 
cDNA size: 702bp order
Price (Cloning Vector): $125 (pGEM-T Vector)
Price (Expression Vector): $325  (pCMV / hygro)
$325 (pCMV / hygro - HA)
$325 (pCMV / hygro - His)
$325 (pCMV / hygro - Myc)
$325 (pCMV / hygro - FLAG)

Canine TNF-alpha cDNA Clone

Canine TNFa Gene cDNA Clone / ORF Clone (DG70003-M)
 
cDNA size: 702bp order
Price (Cloning Vector): $95 (pMD18-T Simple Vector)
Price (Expression Vector): $295  (pCMV / hygro)
$295 (pCMV / hygro - HA)
$295 (pCMV / hygro - His)
$295 (pCMV / hygro - Myc)
$295 (pCMV / hygro - FLAG)

Ferret TNF-alpha cDNA Clone

Ferret TNFA / TNF-alpha Gene cDNA Clone / ORF Clone (FG60002-G)
 
cDNA size: 702bp order
Price (Cloning Vector): $95 (pGEM-T Vector)

TNF-alpha ELISA Kit (Tumor Necrosis Factor Alpha ELISA Kit)

TNFa / TNF-alpha / TNFSF2 ELISA Pair Set (SEKA10602)
 
Detection Limit: 7.8125 pg/ml
Price/Size: $350 / 5 Platesorder

 

TNF-alpha Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>TNF-alpha

Cancer>>Cancer Biomarkers>>TNF-alpha

Immunology>>Cytokine & Receptor>>TNF Superfamily>>TNF-alpha

TNF-alpha Alternative Names

TNF-alpha, TNF, TNFA, TNFSF2, DADB-70P7.1, DIF [Homo sapiens]

TNF-alpha, Tnf, Tnfa, TNFSF2, TNFalpha, Tnfsf1a, DIF, MGC151434 [Mus musculus]

What is tumor necrosis factor (TNF)

Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.

Tumor Necrosis Factor (TNF) Inhibitors

TNF inhibitors are serious drugs and they do increase the risk of serious infections. The rates however have been less than predicted. Using TNF inhibitor medications in patients who require them does lead to a slightly higher rate of serious infection. The trade-off for the expected improvement in disease control and improved long term outcomes, in a patient who unfortunately isn't doing well on standard non-biologic treatment.

TNF Signaling Pathway

The tumor necrosis factor (TNF) superfamily of cytokines activate signaling pathways for cell survival, death, and differentiation. Members of the tumor necrosis factor superfamily act through ligand-mediated trimerization, causing recruitment of several intracellular adaptors to activate multiple signal transduction pathways. Recruitment of death domain (DD) containing adaptors such as Fas associated death domain (FADD) and TNFR associated DD (TRADD) can lead to the activation of a signal transduction pathway that induces apoptosis. While recruitment of TRAF family proteins can lead to the activation of transcription factors such as, NF-kappaB and JNK thereby promoting cell survival and differentiation as well as immune and inflammatory responses.

Anti TNF Therapy / Anti TNF Drugs

There have been increasing concerns regarding the safety of perioperative anti-tumour necrosis factor (anti-TNF) α agents. The anti-TNF therapies are associated with adverse events including serious infections. In large controlled clinical trials of infliximab (IFX), the percentage of patients with serious infections ranged from 4.0% to 4.6%, and the mortality rate was 0.7% to 1.3%

TNF-alpha Related Studies

  1. Hector J, et al. (2007) TNF-alpha alters visfatin and adiponectin levels in human fat. Horm Metab Res. 39(4): 250-5.
  2. Berthold-Losleben M, et al. (2008) The TNF-alpha System: Functional Aspects in Depression, Narcolepsy and Psychopharmacology. Curr Neuropharmacol. 6(3): 193-202.

TNF Superfamily Ligands

  • EDA-A1 / Ectodysplasin-A1*
  • TNFSF6 / CD95L / CD178*
  • TNFSF12 / TWEAK*
  • TNFSF13 / CD256*
  • TNFSF3 / TNFC / lymphotoxin beta*
  • TNFSF4*
  • TNFSF15*

TNF Receptor Superfamily

  • TNFRSF3 / CD18 / LTBR*
  • TNFRSF10C / CD263 / TRAILR3*
  • TNFRSF18*
  • TNFRSF12A / FN14 / TWEAKR*
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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