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TNF-alpha/TNFA/TNFSF2 Mouse MAb

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    Canine TNFa Antibody Product Information
    Immunogen:Recombinant Canine TNF-alpha Protein (Catalog#70003-DNAE)
    Clone ID:1F8D10
    Ig Type:Mouse IgG1
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Canine TNF-alpha (rCanine TNF-alpha; Catalog #70003-DNAE; NP_001003244.4; Val 77-Leu 233). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
    Other TNFa Antibody Products
    Reactivity: Human  
    Application: B/N  
    • Slide 1
    10602-R10N1-200
    10602-R10N1-500
    200 µg 
    500 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  WB  IP  
    • Slide 1
    • Slide 1
    10602-RP02-50
    10602-RP02-100
    10602-RP02-200
    50 µg 
    100 µg 
    200 µg 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10602-R101-A-100
    10602-R101-A-50
    100 Tests 
    50 Tests 
    Add to Cart
    Reactivity: Human  
    Application: B/N  
    • Slide 1
    10602-MM0N1-500
    10602-MM0N1-200
    500 µg 
    200 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10602-RP01-100
      10602-RP01-400
      10602-RP01-200
      100 µg 
       
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  FCM  
      • Slide 1
      • Slide 1
      10602-MM01-50
      10602-MM01-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  WB  
      • Slide 1
      10602-RP03-100
      10602-RP03-200
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10602-R211-50
        10602-R211-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10602-MM01-F-50
        10602-MM01-F-100
        50 Tests 
        100 Tests 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10602-R101-F-50
        10602-R101-F-100
        50 Tests 
        100 Tests 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10602-R101-P-100
        10602-R101-P-50
        100 Tests 
        50 Tests 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10602-T16-100
          10602-T16-50
          10602-T16-200
          100 µg 
          50 µg 
          200 µg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            10602-RE23-50
            10602-RE23-100
            50 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  
              50349-RP01-400
              50349-RP01-100
              50349-RP01-200
               
              100 µg 
              200 µg 
              Add to Cart
              Reactivity: Mouse  
              Application: ELISA  
                50349-RP02-200
                50349-RP02-50
                50349-RP02-100
                200 µg 
                50 µg 
                100 µg 
                Add to Cart
                Reactivity: Mouse  
                Application: ELISA  
                  50349-R009-50
                  50349-R009-100
                  50 µg 
                  100 µg 
                  Add to Cart
                  Reactivity: Rat  
                  Application: ELISA  
                    80045-RP01-200
                    80045-RP01-100
                    80045-RP01-400
                    200 µg 
                    100 µg 
                     
                    Add to Cart
                    Reactivity: Rat  
                    Application: ELISA  
                      80045-RP02-50
                      80045-RP02-100
                      80045-RP02-200
                      50 µg 
                      100 µg 
                      200 µg 
                      Add to Cart
                      Reactivity: Cynomolgus  
                      Application: ELISA  
                        90330-RP01-400
                        90330-RP01-200
                        90330-RP01-100
                         
                        200 µg 
                        100 µg 
                        Add to Cart
                        Reactivity: Canine  
                        Application: ELISA  
                          70003-R001-50
                          70003-R001-100
                          50 µg 
                          100 µg 
                          Add to Cart
                          Reactivity: Canine  
                          Application: ELISA  
                            70003-RP01-400
                            70003-RP01-100
                            70003-RP01-200
                             
                            100 µg 
                            200 µg 
                            Add to Cart
                            Reactivity: Canine  
                            Application: ELISA  
                              70003-RP02-200
                              70003-RP02-50
                              70003-RP02-100
                              200 µg 
                              50 µg 
                              100 µg 
                              Add to Cart
                              Reactivity: Ferret  
                              Application: ELISA  
                                60002-T16-100
                                60002-T16-50
                                60002-T16-200
                                100 µg 
                                50 µg 
                                200 µg 
                                Add to Cart
                                Reactivity: Ferret  
                                Application: ELISA  
                                  60002-R030-50
                                  60002-R030-100
                                  50 µg 
                                  100 µg 
                                  Add to Cart
                                  Reactivity: Ferret  
                                  Application: ELISA  
                                    60002-MM11-200
                                    60002-MM11-50
                                    60002-MM11-100
                                    200 µg 
                                    50 µg 
                                    100 µg 
                                    Add to Cart
                                    Reactivity: Ferret  
                                    Application: ELISA  
                                      60002-RP01-100
                                      60002-RP01-200
                                      60002-RP01-400
                                      100 µg 
                                      200 µg 
                                       
                                      Add to Cart
                                      TNF-alpha/TNFA/TNFSF2 Background

                                      Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.

                                      TNF-alpha Protein & Antibody

                                      Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                                      Canine TNF-alpha/TNFA/TNFSF2 References
                                    • Hector J, et al. (2007) TNF-alpha alters visfatin and adiponectin levels in human fat. Horm Metab Res. 39(4): 250-5.
                                    • Berthold-Losleben M, et al. (2008) The TNF-alpha System: Functional Aspects in Depression, Narcolepsy and Psychopharmacology. Curr Neuropharmacol. 6(3): 193-202.
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                                      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"