TMEM27

TMEM27 is a membrane protein. It has been proposed as a beta cell mass biomarker since it is cleaved and shed by pancreatic beta cells. TMEM27 plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. Overexpression of TMEM27 leads to increased thymidine incorporation, whereas silencing of Tmem27 using RNAi results in a reduction of cell replication. Furthermore, transgenic mice with increased expression of Tmem27 in pancreatic beta cells exhibit increased beta cell mass. TMEM27 is also important for trafficking amino acid transporters to the apical brush border of proximal tubules.

TMEM27 Related Areas

 

TMEM27 Alternative Names

UNQ679/PRO1312, NX-17, NX17, 0610008J07Rik, collectrin, kidney-specific membrane protein [Homo sapiens]

RP23-59N7.2, 0610008J07Rik, NX-17, NX17, collectrin, kidney-specific membrane protein [Mus musculus]

Summaries for TMEM27

Entrez Gene summary for TMEM27:

This TMEM27 gene encodes a transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. TMEM27 also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. [provided by RefSeq, Nov 2009]

Human TMEM27 Protein General Information

 

• Protein names: Transmembrane protein 27
• Sequence length: 222 AA.
• Sequence similarities: TMEM27 belongs to the TMEM27 family.
• Post-translational modification: Glycosylated. The extracellular domain is cleaved and released from the cell membrane of pancreatic beta cells
• Subunit structure: Homodimer. TMEM27 associates with SLC6A18. TMEM27 interacts with SNAPIN.
• Subcellular location: Membrane; Single-pass type I membrane protein
• Tissue specificity: Kidney; collecting ducts. Pancreas; beta cells of islets.
• Sequence caution: The sequence AAQ89419.1 differs from that shown. Reason: Frameshift at position 207.

General information above from UniProt

Function for TMEM27 Protein

UniProtKB:

TMEM27 is regulator of SNARE complex function. TMEM27 is stimulator of beta cell replication.

Genatlas:

• TMEM27 is key regulator of renal amino acid uptake
• TMEM27 is regulator of SNARE complex function
• TMEM27 is stimulator of beta cell replication

Homology for human TMEM27

• homolog to murine Tmem27 (84.7pc)
• homolog to rattus Tmem27 (84.7pc)
• homolog to ACE2