TLR3 Protein & Antibody (CD283)

Toll-Like Receptor 3 (Cluster of Differentiation 283)

TLR3 Products

TLR3 Protein, Recombinant

Molecule	Species	Description	Cat. No
TLR3	Mouse	TLR3 Protein, Recombinant	50161-M08H
TLR3	Mouse	TLR3 Protein, Recombinant	50161-M08B

TLR3 Antibody

Molecule	Application	Description	Cat. No
Mouse	WB, ELISA	TLR3 Antibody, Rabbit PAb	50161-RP01
Mouse	WB, ELISA	TLR3 Antibody, Rabbit PAb (Antigen Affinity Purified)	50161-RP02

TLR3 cDNA Clone

Molecule	Species	Description	Cat. No
TLR3	Human	Homo sapiens TLR3/CD283 DNA ORF Clone	HG10190-M
TLR3	Mouse	Mus musculus TLR3/CD283 cDNA Clone	MG50161-M

TLR3 Related Areas

Immunology>>Adaptive Immunity>>T Cell>>T Cell Antigen Recognition>>TLR3

Immunologyy>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family>>TLR3

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Pathogen Recognition/Uptake>>TLR3

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Lineage Markers>>TLR3

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>TLR3

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Antigen Recognition>>TLR3

TLR3 Alternative Names

TLR3, CD283 [Homo sapiens]

Tlr3, AI957183 [Mus musculus]

TLR3 Background

Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3/CD283 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses.

TLR3 Related Studies

1. Muzio M, et al.. (2000) Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol. 164(11): 5998-6004.
2. Doyle S, et al.. (2002) IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity. 17(3): 251-63.
3. Choe J, et al.. (2005) Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science. 309(5734): 581-5.