Anti-TLR3 Antibody

Cat: 50161-RP01
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Anti-TLR3 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-TLR3 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse TLR3
Immunogen
Recombinant Mouse TLR3 protein (Catalog#50161-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse TLR3 (rM TLR3; Catalog#50161-M08H; NP_569054.2; Met 1-Leu 705). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TLR3 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TLR3 Antibody Alternative Names
Anti-AI957183 Antibody;Anti-Tlr3 Antibody
TLR3 Background Information

Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3/CD283 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
toll like receptor 3
References
  • Muzio M, et al.. (2000) Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol. 164(11): 5998-6004.
  • Doyle S, et al.. (2002) IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity. 17(3): 251-63.
  • Choe J, et al.. (2005) Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science. 309(5734): 581-5.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TLR3 Antibody Rabbit Monoclonal ELISA 50161-R002
    Anti-TLR3 Antibody Rabbit Polyclonal ELISA 50161-T16
    Anti-TLR3 Antibody Rabbit Polyclonal ELISA 50161-RP02
    Anti-TLR3 Antibody Rabbit Polyclonal IHC-P,ICC/IF,IF 106769-T10
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