TLE3

TLE3 (transducin-like enhancer of split 3), and several other members of the Gro/TLE family of groucho-related genes are expressed during pituitary development. The transducin-like enhancers of split are a family of mammalian proteins that share sequence homology with the Drosophila protein Groucho. TLE1 and TLE3 a have similar protein structure, and their patterns of expression during pituitary development are overlapping, but distinct. The groucho family member TLE3 is a transcriptional integrator of the PPAR? and Wnt pathways. TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1.

TLE3 Related Areas

Signal Transduction>>Transcription Factor & Regulator>>TLE3

TLE3 Alternative Names

TLE3, ESG, ESG3, FLJ39460, GRG3, HsT18976, KIAA1547 [Homo sapiens]

Tle3, 2610103N05Rik, ESG, Grg3a, Grg3b, mKIAA1547 [Mus musculus]

Summaries for TLE3

Wikipedia summary for TLE3:

Transducin-like enhancer protein 3 is a protein that in humans is encoded by the TLE3 gene.

Human TLE3 Protein General Information

 

• Protein names: Transducin-like enhancer protein 3
  Short name=TLE3
• Sequence length: 772 AA.
• Domain: Repeat
  WD repeat
• Sequence similarities: Belongs to the WD repeat Groucho/TLE family.
  Contains 7 WD repeats.
• Post-translational modification: Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.
• Subunit structure: Homotetramer and heterooligomer with other family members. Binds LEF1, TCF7 and TCF7L1 By similarity. Binds FOXA2. Interacts with XIAP/BIRC4 and TCF7L2/TCF4.
• Subcellular location: Nucleus.
• Tissue specificity: Placenta and lung.
• Sequence caution: The sequence BAB13373.1 differs from that shown. Reason: Erroneous initiation.

General information above from UniProt

Function for TLE3 Protein

UniProtKB:

TLE3 is transcriptional corepressor that binds to a number of transcription factors. TLE3 inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.

Genatlas:

• TLE3 is transcriptional corepressor binding to a number of transcription factors
• TLE3 inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling
• TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1 (Carvalho 2010)

Homology for human TLE3

• homolog to Drosophila split Groucho (Notch signaling pathway)
• homolog to murine Tle3 (98.8pc)
• homolog to rattus Tle3 (99.2pc)