TLE3 Protein

Transducin-like enhancer of split 3

TLE3 Products

TLE3 Protein, Recombinant

Molecule	Species	Description	Cat. No
TLE3	Human	TLE3 (aa 484-772) Protein, Recombinant, with GST Tag	13099-H09E

TLE3 Related Areas

Signal Transduction>>Transcription Factor & Regulator>>TLE3

TLE3 Alternative Names

TLE3, ESG, ESG3, FLJ39460, GRG3, HsT18976, KIAA1547 [Homo sapiens]

Tle3, 2610103N05Rik, ESG, Grg3a, Grg3b, mKIAA1547 [Mus musculus]

TLE3 Background

TLE3 (transducin-like enhancer of split 3), and several other members of the Gro/TLE family of groucho-related genes are expressed during pituitary development. The transducin-like enhancers of split are a family of mammalian proteins that share sequence homology with the Drosophila protein Groucho. TLE1 and TLE3 a have similar protein structure, and their patterns of expression during pituitary development are overlapping, but distinct. The groucho family member TLE3 is a transcriptional integrator of the PPAR? and Wnt pathways. TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1.

TLE3 Related Studies

1. Villanueva CJ, et al. (2011) TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metab. 13(4): 413-27.
2. Carvalho LR, et al. (2010) Corepressors TLE1 and TLE3 interact with HESX1 and PROP1. Mol Endocrinol. 24(4): 754-65.
3. Nakaya HI, et al. (2007) Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumors. Biochem Biophys Res Commun. 364(4): 918-23.
4. Brinkmeier ML, et al. (2003) TCF and Groucho-related genes influence pituitary growth and development. Mol Endocrinol. 17: 2152-2161.
5. Dasen JS, et al. (2001) Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. Genes Dev. 15: 3193-3207.
6. Douglas KR, et al. (2001) Identification of members of the Wnt signaling pathway in the embryonic pituitary gland. Mamm Genome. 12: 843-851.
7. Chen G, et al. (2000) Groucho/TLE family proteins and transcriptional repression. Gene. 249: 1-16.