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TLE3  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: E. coli  
  • Slide 1
13099-H09E-100
13099-H09E-20
100 µg 
20 µg 
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TLE3 Related Pathways

TLE3 Related Protein, Antibody, cDNA Gene, and ELISA Kits

TLE3 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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TLE3 Summary & Protein Information

TLE3 Background

Subunit structure: Homotetramer and heterooligomer with other family members. Binds LEF1, TCF7 and TCF7L1 (By similarity). Binds FOXA2. Interacts with XIAP/BIRC4 and TCF7L2/TCF4.
Subcellular location: Nucleus.
Tissue specificity: Placenta and lung.
Post-translational: Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.
Sequence similarity: Belongs to the WD repeat Groucho/TLE family.
Contains 7 WD repeats.
General information above from UniProt

TLE3 Alternative Name

ESG3,GRG3,HsT18976,ESG, [homo-sapiens]
GRG3,TLE3,ESG,ESG3,FLJ39460,HsT18976,KIAA1547, [human]
Grg3a,Tle3,2610103N05Rik,ESG,Grg3b,mKIAA1547, [mouse]
ESG,Grg3a,Grg3b,mKIAA1547,2610103N05Rik, [mus-musculus]

TLE3 Related Studies

  • Villanueva CJ, et al. (2011) TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metab. 13(4): 413-27.
  • Carvalho LR, et al. (2010) Corepressors TLE1 and TLE3 interact with HESX1 and PROP1. Mol Endocrinol. 24(4): 754-65.
  • Nakaya HI, et al. (2007) Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumors. Biochem Biophys Res Commun. 364(4): 918-23.
  • Brinkmeier ML, et al. (2003) TCF and Groucho-related genes influence pituitary growth and development. Mol Endocrinol. 17: 2152-2161.
  • Dasen JS, et al. (2001) Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. Genes Dev. 15: 3193-3207.
  • Douglas KR, et al. (2001) Identification of members of the Wnt signaling pathway in the embryonic pituitary gland. Mamm Genome. 12: 843-851.
  • Chen G, et al. (2000) Groucho/TLE family proteins and transcriptional repression. Gene. 249: 1-16.
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