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TLE3 Protein, Antibody, ELISA Kit, cDNA Clone

TLE3 Related Areas

TLE3 Related Pathways

TLE3 Related Product

    TLE3 Summary & Protein Information

    TLE3 Background

    Subunit structure: Homotetramer and heterooligomer with other family members. Binds LEF1, TCF7 and TCF7L1 (By similarity). Binds FOXA2. Interacts with XIAP/BIRC4 and TCF7L2/TCF4.
    Subcellular location: Nucleus.
    Tissue specificity: Placenta and lung.
    Post-translational: Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.
    Sequence similarity: Belongs to the WD repeat Groucho/TLE family.
    Contains 7 WD repeats.
    General information above from UniProt

    TLE3 Alternative Name

    GRG3,TLE3,ESG,ESG3,FLJ39460,HsT18976,KIAA1547, [human]
    Grg3a,Tle3,2610103N05Rik,ESG,Grg3b,mKIAA1547, [mouse]

    TLE3 Related Studies

  • Villanueva CJ, et al. (2011) TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metab. 13(4): 413-27.
  • Carvalho LR, et al. (2010) Corepressors TLE1 and TLE3 interact with HESX1 and PROP1. Mol Endocrinol. 24(4): 754-65.
  • Nakaya HI, et al. (2007) Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumors. Biochem Biophys Res Commun. 364(4): 918-23.
  • Brinkmeier ML, et al. (2003) TCF and Groucho-related genes influence pituitary growth and development. Mol Endocrinol. 17: 2152-2161.
  • Dasen JS, et al. (2001) Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. Genes Dev. 15: 3193-3207.
  • Douglas KR, et al. (2001) Identification of members of the Wnt signaling pathway in the embryonic pituitary gland. Mamm Genome. 12: 843-851.
  • Chen G, et al. (2000) Groucho/TLE family proteins and transcriptional repression. Gene. 249: 1-16.
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