TL1A (TNFSF15)

TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis. TL1A is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.

TL1A (TNFSF15) Related Areas

Immunology>>Cytokine & Receptor>>TNF Superfamily>>TL1A / TNFSF15

TL1A (TNFSF15) Alternative Names

TL1, TL1A, VEGI, VEGI192A, TNF ligand-related molecule 1, TNF superfamily ligand TL1A, tumor necrosis factor ligand superfamily member 15, vascular endothelial cell growth inhibitor, vascular endothelial growth inhibitor-192A [Homo sapiens]

Tl1, Tl1a, Vegi, TNF ligand-related molecule 1, bM20K13.3 (tumor necrosis factor (ligand) superfamily, member 15), tumor necrosis factor ligand superfamily member 15, vascular endothelial cell growth inhibitor, vascular endothelial growth inhibitor [Mus musculus]

Summaries for TL1A (TNFSF15)

Entrez Gene summary for TNFSF15:

The protein encoded by this TNFSF15 gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This TL1A protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this TL1A protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. TL1A can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

OMIM - description for TL1A:

Members of the tumor necrosis factor (TNF; 191160) and TNF receptor (TNFR) superfamilies regulate diverse biologic functions, including cell proliferation, immune regulation, and inflammation. See 191190.

Wikipedia summary for TL1A:

TL1A is an anti-angiogenic protein. TL1A belongs to tumor necrosis factor (ligand) superfamily, where it is member 15. TNFSF15 is the human gene for it.

Human TL1A (TNFSF15) Protein General Information

 

• Protein names: Tumor necrosis factor ligand superfamily member 15
• Sequence length: 251 AA.
• Sequence similarities: TL1A belongs to the tumor necrosis factor family.
• Subunit structure: Homotrimer.
• Subcellular location: Membrane; Single-pass type II membrane protein. Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted
• Tissue specificity: TL1A is specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.
• Induction: Up-regulated by IL1A/interleukin-1 alpha and TNF.

General information above from UniProt

Function for TL1A (TNFSF15) Protein

UniProtKB:

TL1A is receptor for TNFRSF25 and TNFRSF6B. TL1A mediates activation of NF-kappa-B. TL1A inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis.

Genatlas:

• TL1A is modulator of vascular homeostasis
• TL1A may play an important role in a Th1-mediated disease such as Crohn disease
• TL1A is angiogenesis inhibitor of the TNF family and functioning in part by directly inhibiting endothelial cell proliferation
• TL1A acts as an autocrine factor to induce apoptosis in endothelial cells
• TL1A can activate NF-KappaB and MAP kinases
• TL1A may serve as an inflammatory marker in rhumatoid arthritis (Bomias 2008)
• TL1A may contribute to renal inflamattion and injury through TNFRSF25-mediated activation of NF-KappaB and caspase 3 (Al-Lamki 2008)
• TL1A is involved in Th1 response to pathogens (Prehn 2007)
• TL1A is involved in atherosclerosis via the induction of proinflammatory cytokines/chemokines and decreasing plaque stability by inducing extracellular matrix degrading enzymes (Kang 2005)

Homology for human TL1A (TNFSF15)

• homolog to rattus Tnfsf15 (70.9pc)