TIMP-1 / TIMP1 Protein & Antibody

Tissue Inhibitor of Metalloproteinase 1

TIMP-1 / TIMP1 Products

TIMP-1 / TIMP1 Protein, Recombinant

Molecule	Species	Description	Cat. No
TIMP-1/TIMP1	Human	TIMP-1/TIMP1 Protein, Recombinant	10934-H08H
TIMP-1/TIMP1	Human	TIMP1/TIMP1 Protein, Recombinant	10934-HNAH
TIMP-1/TIMP1	Mouse	TIMP-1/TIMP1 Protein, Recombinant	50342-MNAH

  10934-H08H: The IC₅₀ value is approximately 6 nM. Measured by its ability to inhibit human MMP­2 cleavage of a fluorogenic peptide substrate MCA-PLGL-DPA-AR-NH2 (R&D Systems, Catalog # ES001).

  10934-HNAH: The IC₅₀ value is approximately 6 nM. Measured by its ability to inhibit human MMP­2 cleavage of a fluorogenic peptide substrate MCA-PLGL-DPA-AR-NH2 (R&D Systems, Catalog # ES001).

  50342-MNAH: The IC₅₀ value is < 6 nM. Measured by its ability to inhibit human MMP­2 cleavage of a fluorogenic peptide substrate MCA-PLGL-DPA-AR-NH2 (R&D Systems, Catalog # ES001).

TIMP-1 / TIMP1 Antibody

Molecule	Application	Description	Cat. No
Human TIMP-1/TIMP1	ELISA	Mouse Monoclonal Antibody	10934-MM02
Human TIMP-1/TIMP1	WB, ELISA	Mouse Monoclonal Antibody	10934-MM03
Human TIMP-1/TIMP1	WB, ELISA	TIMP-1/TIMP1 Antibody, Rabbit MAb	10934-R004
Human TIMP-1/TIMP1	ELISA	Rabbit Polyclonal Antibody	10934-RP01
Human TIMP-1/TIMP1	WB	Rabbit Polyclonal Antibody(Antigen Affinity Purified)	10934-RP04

TIMP-1 / TIMP1 ELISA Kit

Molecule	Application	Description	Cat. No
Human TIMP-1/TIMP1	ELISA	TIMP-1/TIMP1 ELISA Kit	SEK10934

TIMP-1 / TIMP1 cDNA Clone

Molecule	Species	Description	Cat. No
TIMP-1/TIMP1	Human	Homo sapiens TIMP-1/TIMP1 cDNA Clone(NM_003254.2)	HG10934-M
TIMP-1/TIMP1	Mouse	Mus musculus TIMP-1/TIMP1 cDNA Clone	MG50342-M
TIMP-1/TIMP1	Rat	Rat TIMP-1/TIMP1 cDNA Clone / ORF Clone	RG80064-M

TIMP-1 / TIMP1 Related Areas

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>Tissue Inhibitor of Metalloproteinase>>TIMP-1/TIMP1

Cancer>>Angiogenesis>>Tissue Inhibitor of Metalloproteinase>>TIMP-1/TIMP1

Cancer>>Cancer Biomarkers>>TIMP-1/TIMP1

TIMP-1 / TIMP1 Alternative Names

TIMP1, TIMP, RP1-230G1.3, CLGI, EPA, EPO, FLJ90373, HCI [Homo sapiens]

TIMP-1, Timp1, Timp, RP23-132C19.3, Clgi, MGC7143 [Mus musculus]

TIMP-1 / TIMP1 Background

TIMP metallopeptidase inhibitor 1, also known as TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating activity, TPA-S1TPA-induced proteinTissue inhibitor of metalloproteinases 1, is a natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. TIMP-1/TIMP1 is found in fetal and adult tissues. Highest levels are found in bone, lung, ovary and uterus. Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-1/TIMP1 mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. In addition to its inhibitory role against most of the known MMPs, the protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this protein encoding gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This encoding gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-1/TIMP1 is Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16.

TIMP-1 / TIMP1 Related Studies

1. Hornebeck W (2004). "Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival.". Pathol. Biol. 51 (10): 569–73.
2. Soini Y, et al. (2001) Expression of MMP2, MMP9, MT1-MMP, TIMP-1, and TIMP2 mRNA in valvular lesions of the heart. J Pathol. 194(2):225-31.
3. Wang X, et al. (1999) Analysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP-1) and 2 (TIMP2) in patients with aneurysms. Matrix Biol. 18(2):121-4.

TIMP-1 / TIMP1 Related Products

Protein Products

Molecule	Species	Description
TIMP-2/TIMP2	Human	TIMP-2/TIMP2/Fc Protein, Recombinant
TIMP-2/TIMP2	Human	TIMP-2/TIMP2 Protein, Recombinant

cDNA Clone Products

Molecule	Species	Description
TIMP-2/TIMP2	Human	Homo sapiens TIMP-2/TIMP2  cDNA Clone(NM_003255.4)
TIMP-3/TIMP3	Human	Homo sapiens TIMP-3/TIMP3 cDNA Clone(NM_000362.4)
TIMP-4/TIMP4	Human	Homo sapiens TIMP-4/TIMP cDNA Clone(NM_003256.2)