A type I transmembrane protein called TIMD4 (T-cell immunoglobulin- and mucin-domain-containing molecule; also known as TIM4), which belongs to the immunoglobulin superfamily and TIM family. TIMD4 is involved in regulating T-cell proliferation and lymphotoxin signaling. It is a ligand for HAVCR1/TIMD1. Recent reports indicate that dendritic cell (DC)-derived T-cell immunoglobulin and mucin domain molecule (TIM)-4, which is expressed on dendritic cells and macrophages, plays an important role in the initiation of T(H)2 polarization. TIMD4 bound apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. The expression of TIMD4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIMD4 is phosphatidylserine receptor for the engulfment of apoptotic cells, and may also be involved in intercellular signalling in which exosomes are involved. Modulation of TIMD4 production in dendritic cells (DCs) represents a novel therapeutic approach for the treatment of peanut allergy. The interaction of TIM1/TIMD4 played a critical role in sustaining the polarization status of Th2 cells in allergic rhinitis (AR) patients. Cross-linking FcgammaRI by antigen/IgG complexes increased the production of TIMD4 by dendritic cells via upregulating tumor necrosis factor-alpha in DCs. Specific immunotherapy (SIT) suppresses the skewed Th2 responses via disrupting the interaction of TIM1/TIMD4 in antigen-specific Th2 cells.
TIMD4 (TIM4) Proteins
- Human TIMD4 Protein, Recombinant, Cat NO:12161-H08H
- Mouse TIMD4 Protein, Recombinant, Cat NO:50388-M08H
TIMD4 (TIM4) Antibodies
- Anti-Mouse TIMD4 Antibody, Rabbit PAb, Cat NO:50388-RP01
- Anti-Mouse TIMD4 Antibody, Rabbit PAb (Antigen Affinity Purified), Cat NO:50388-RP02
TIMD4 (TIM4) ELISA Pair sets
TIMD4 (TIM4) cDNA Clones
- Human TIMD4 cDNA Clone / ORF Clone, Cat NO:HG12161-G
- Mus musculus TIMD4/TIM4 cDNA Clone, Cat NO:MG50388-M
TIM4, TIM-4, TIMD4, TIMD-4, FLJ27515, SMUCKLER, T-cell membrane protein 4 [Homo sapiens]
Tim4, TIM-4, Timd4, TIMD-4, RP23-43C21.2, B430010N18Rik, T-cell membrane protein 4 [Mus musculus]
T-cell immunoglobulin and mucin domain-containing protein 4
Recognizes phosphatidyl serine via its immunoglobulin domain.
Belongs to the immunoglobulin superfamily. TIM family.
|Subcellular location:||Membrane; Single-pass type I membrane protein|
General information above from UniProt
TIMD4 is phosphatidylserine receptor that enhances the engulfment of apoptotic cells. TIMD4 is involved in regulating T-cell proliferation and lymphotoxin signaling. TIMD4 is ligand for HAVCR1/TIMD1.
- TIMD4 is phosphatidylserine receptor for the engulfment of apoptotic cells, and may also be involved in intercellular signalling in which exosomes are involved