TIMD4 (TIM4)

A type I transmembrane protein called TIMD4 (T-cell immunoglobulin- and mucin-domain-containing molecule; also known as TIM4), which belongs to the immunoglobulin superfamily and TIM family. TIMD4 is involved in regulating T-cell proliferation and lymphotoxin signaling. It is a ligand for HAVCR1/TIMD1. Recent reports indicate that dendritic cell (DC)-derived T-cell immunoglobulin and mucin domain molecule (TIM)-4, which is expressed on dendritic cells and macrophages, plays an important role in the initiation of T(H)2 polarization. TIMD4 bound apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. The expression of TIMD4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIMD4 is phosphatidylserine receptor for the engulfment of apoptotic cells, and may also be involved in intercellular signalling in which exosomes are involved. Modulation of TIMD4 production in dendritic cells (DCs) represents a novel therapeutic approach for the treatment of peanut allergy. The interaction of TIM1/TIMD4 played a critical role in sustaining the polarization status of Th2 cells in allergic rhinitis (AR) patients. Cross-linking FcgammaRI by antigen/IgG complexes increased the production of TIMD4 by dendritic cells via upregulating tumor necrosis factor-alpha in DCs. Specific immunotherapy (SIT) suppresses the skewed Th2 responses via disrupting the interaction of TIM1/TIMD4 in antigen-specific Th2 cells.

TIMD4 (TIM4) Related Areas

Immunology>>Adaptive Immunity>>T Cell>>T Cell Antigen Recognition>>TIM4

TIMD4 (TIM4) Alternative Names

TIM4, TIM-4, TIMD4, TIMD-4, FLJ27515, SMUCKLER, T-cell membrane protein 4 [Homo sapiens]

Tim4, TIM-4, Timd4, TIMD-4, RP23-43C21.2, B430010N18Rik, T-cell membrane protein 4 [Mus musculus]

Human TIMD4 (TIM4) Protein General Information

 

• Protein names: T-cell immunoglobulin and mucin domain-containing protein 4
  Short name=TIMD4
• Sequence length: 378 AA.
• Domain: Recognizes phosphatidyl serine via its immunoglobulin domain.
• Sequence similarities: Belongs to the immunoglobulin superfamily. TIM family.
  Contains 1 Ig-like V-type (immunoglobulin-like) domain.
• Subcellular location: Membrane; Single-pass type I membrane protein

General information above from UniProt

Function for TIMD4 (TIM4) Protein

UniProtKB:

TIMD4 is phosphatidylserine receptor that enhances the engulfment of apoptotic cells. TIMD4 is involved in regulating T-cell proliferation and lymphotoxin signaling. TIMD4 is ligand for HAVCR1/TIMD1.

Genatlas:

• TIMD4 is phosphatidylserine receptor for the engulfment of apoptotic cells, and may also be involved in intercellular signalling in which exosomes are involved