TIMD4 / TIM4 Protein & Antibody

T-cell immunoglobulin and mucin domain containing 4

TIM4 Products

TIM4 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
TIM4	Human	TIM4 Protein, Recombinant	12161-H08H
TIM4	Mouse	TIM4 Protein, Recombinant	50388-M08H

TIM4 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse TIM4	WB, ELISA	TIM4 Antibody, Rabbit PAb	50388-RP01
Mouse TIM4	WB, ELISA	TIM4 Antibody, Rabbit PAb (Antigen Affinity Purified)	50388-RP02
Mouse TIM4	ELISA	TIM4 / TIMD4 Antibody	50388-R102

TIM4 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
TIM4	Human	TIMD4 cDNA Clone / ORF Clone	HG12161-G
TIM4	Mouse	Mus musculus TIMD4/TIM4 cDNA Clone	MG50388-M

TIM4 Related Areas

Immunology>>Adaptive Immunity>>T Cell>>T Cell Antigen Recognition>>TIM4

TIM4 Alternative Names

TIM4, TIM-4, TIMD4, TIMD-4, FLJ27515, SMUCKLER, T-cell membrane protein 4 [Homo sapiens]

Tim4, TIM-4, Timd4, TIMD-4, RP23-43C21.2, B430010N18Rik, T-cell membrane protein 4 [Mus musculus]

TIM4 Background

A type I transmembrane protein called TIM4 (T-cell immunoglobulin- and mucin-domain-containing molecule; also known as TIMD4), which belongs to the immunoglobulin superfamily and TIM family. TIM4 is involved in regulating T-cell proliferation and lymphotoxin signaling. It is a ligand for HAVCR1/TIMD1. Recent reports indicate that dendritic cell (DC)-derived T-cell immunoglobulin and mucin domain molecule (TIM)-4, which is expressed on dendritic cells and macrophages, plays an important role in the initiation of T(H)2 polarization. TIM4 bound apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. The expression of TIM4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIM4 is phosphatidylserine receptor for the engulfment of apoptotic cells, and may also be involved in intercellular signalling in which exosomes are involved. Modulation of TIM4 production in dendritic cells (DCs) represents a novel therapeutic approach for the treatment of peanut allergy. The interaction of TIM1/TIM4 played a critical role in sustaining the polarization status of Th2 cells in allergic rhinitis (AR) patients. Cross-linking FcgammaRI by antigen/IgG complexes increased the production of TIM4 by dendritic cells via upregulating tumor necrosis factor-alpha in DCs. Specific immunotherapy (SIT) suppresses the skewed Th2 responses via disrupting the interaction of TIM1/TIM4 in antigen-specific Th2 cells.

TIM4 Related Studies

1. Miyanishi M, et al. (2007) Identification of Tim4 as a phosphatidylserine receptor. Nature. 450(7168): 435-9.
2. Feng BS, et al. (2008) Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)-1/TIM4 interaction as a therapeutic strategy in a dendritic cell-induced peanut allergy model. J Allergy Clin Immunol. 122(1): 55-61.
3. Cai PC, et al. (2009) Association of TIM4 promoter polymorphism -1419G>A with childhood asthma in a Chinese Han population. Tissue Antigens. 74(1): 11-6.
4. Zhao CQ, et al. (2010) Specific immunotherapy suppresses Th2 responses via modulating TIM1/TIM4 interaction on dendritic cells. Allergy. 65(8): 986-95.