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Human TIM-3 / HAVCR2 / TIMD3 ELISA Pair Set
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Human TIM-3 / HAVCR2 / TIMD3 ELISA Pair Set PDF Download

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SEK10390  

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Human TIM-3 / HAVCR2 / TIMD3 ELISA Pair Set

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High affinity Human TIM-3 / HAVCR2 / TIMD3 ELISA Pair Set
Detection limit - 31.25 pg/ml
Affordable price and 30%-80% cost saving for Bulk order
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Background

Hepatitis A virus cellular receptor 2 ( HAVCR2 ), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. TIM-3 thus serves as the surface molecule that distinguishes between the two effector populations derived from naive CD4(+) T-helper cells. TIM-3 is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. Th1 cells produce cytokines ( IFN-gamma, interleukin-2, TNF-alpha and lymphotoxin ) that are commonly associated with cell-mediated immune responses against intracellular pathogens, delayed-type hypersensitivity reactions, and induction of organ-specific autoimmune diseases. It has been identified that galectin-9 is the Tim-3 ligand, and the TIM-3-galectin-9 pathway may serve to inhibit Th1 cells during a normal immune response and may be crucial for the induction of peripheral tolerance. Dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

 
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