After search, choose a molecule or a kind of categories listed in the left to narrow down your filter. If you have any problems, please contact us!

Quick Order

TIM-3 / HAVCR2 Antibody, Rabbit PAb, Antigen Affinity Purified

DatasheetReviewsRelated ProductsProtocols
Human TIM3 Antibody Product Information
Immunogen:Recombinant Human TIMD3 protein (Catalog#10390-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human TIMD3 (rh TIMD3; Catalog#10390-H08H; NP_116171.3; Met 1-Arg 200). TIMD3 specific IgG was purified by human TIMD3 affinity chromatography .
Human TIM3 Antibody Usage Guide
Specificity:Human TIMD3 / HAVCR2
Application:ELISA

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TIMD3. The detection limit for Human TIMD3 is approximately 0.00245 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other TIM3 Antibody Products
Reactivity: Human  
Application: ELISA  
    10390-R108-100
    10390-R108-50
    100 µg 
    50 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10390-MM04-50
      10390-MM04-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10390-RP01-100
        10390-RP01-200
        100 µg 
        200 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10390-R024-50
          10390-R024-100
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Mouse  
          Application: ELISA  
            51152-RP01-400
            51152-RP01-200
            51152-RP01-100
             
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  WB  IP  
            • Slide 1
            • Slide 1
            51152-T52-50
            51152-T52-200
            51152-T52-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            TIM-3/HAVCR2  Background

            Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both mice and human. Recently, identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In tumor rejection model, soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response.

            Human TIM-3/HAVCR2  References
          • Geng H, et al. (2006) Soluble form of T cell Ig mucin 3 is an inhibitory molecule in T cell-mediated immune response. J Immunol. 176(3): 1411-20.
          • Anderson AC, et al. (2006) TIM-3 in autoimmunity. Curr Opin Immunol. 18(6): 665-9.
          • Anderson DE. (2007) TIM-3 as a therapeutic target in human inflammatory diseases. Expert Opin Ther Targets. 11(8): 1005-9.
          • Pan HF, et al. (2010) TIM-3 as a new therapeutic target in systemic lupus erythematosus. Mol Biol Rep. 37(1): 395-8.
          • Product nameProduct name
            Size / Price
            Catalog: 10390-RP02-50
            List Price: 
            Price:      (You Save: )
            All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
            Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"