THSD1 Protein & Antibody

Thrombospondin, type I, domain containing 1

THSD1 Products

THSD1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
THSD1	Mouse	THSD1 Protein, Recombinant	50400-M08H

THSD1 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat No
Mouse THSD1	WB, ELISA	THSD1 Antibody, Rabbit PAb	50400-RP01
Mouse THSD1	WB, ELISA	THSD1 Antibody, Rabbit PAb (Antigen Affinity Purified)	50400-RP02

THSD1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
THSD1	Mouse	Mus musculus THSD1 cDNA Clone	MG50400-M

THSD1 Related Areas

Cancer>>Angiogenesis>>ECM Molecules in Angiogenesis>>THSD1

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>THSD1

THSD1 Alternative Names

THSD1, RP11-245D16.1, MGC74971, TMTSP, UNQ3010 [Homo sapiens]

Thsd1, 4833423O18Rik, AW121720, Tmtsp [Mus musculus]

THSD1 Background

Thrombospondin type-1 domain-containing protein 1, also known as transmembrane molecule with thrombospondin module, THSD1 and TMTSP, is a single-pass type I membrane protein which contains one TSP type-1 domain. THSD1 is a multi-domain, multi-functional glycoprotein synthesized by many cells. Matricellular THSD1 modulates cell adhesion and proliferation. It is involved in angiogenesis, inflammation, wound healing and cancer. In vitro, nanomolar concentrations of Thrombospondin-1 are required to alter endothelial and vascular smooth muscle cell adhesion, proliferation, motility, and survival. As a major platelet protein, for a long time it was postulated to control hemostasis via platelet aggregate stabilization. THSD1 is a potent angiogenesis inhibitor, and down-regulation of THSD1 has been suggested to alter tumor growth by modulating angiogenesis in a variety of tumor types.

THSD1 Related Studies

1. Lawler J. (2002) Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth. J Cell Mol Med. 6(1): 1-12.
2. Ren B, et al. (2006) Regulation of tumor angiogenesis by thrombospondin-1. Biochim Biophys Acta. 1765(2): 178-88.
3. Mirochnik Y, et al. (2008) Thrombospondin and apoptosis: molecular mechanisms and use for design of complementation treatments. Curr Drug Targets. 9(10): 851-62.
4. Bonnefoy A, et al. (2008) The evolving role of thrombospondin-1 in hemostasis and vascular biology. Cell Mol Life Sci. 65(5): 713-27.
5. Isenberg JS, et al. (2008) Thrombospondin-1: a physiological regulator of nitric oxide signaling. Cell Mol Life Sci. 65(5): 728-42.