Anti-THSD1 Antibody

Cat: 50400-RP02
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Anti-THSD1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-THSD1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse THSD1
Immunogen
Recombinant Mouse THSD1 protein (Catalog#50400-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse THSD1 (rM THSD1; Catalog#50400-M08H; NP_062522.1; Met 1-Asn 412). THSD1 specific IgG was purified by mouse THSD1 affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-THSD1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-THSD1 Antibody Alternative Names
Anti-4833423O18Rik Antibody;Anti-Tmtsp Antibody
THSD1 Background Information

Thrombospondin type-1 domain-containing protein 1, also known as transmembrane molecule with thrombospondin module, THSD1 and TMTSP, is a single-pass type I membrane protein which contains one TSP type-1 domain. THSD1 is a multi-domain, multi-functional glycoprotein synthesized by many cells. Matricellular THSD1 modulates cell adhesion and proliferation. It is involved in angiogenesis, inflammation, wound healing and cancer. In vitro, nanomolar concentrations of Thrombospondin-1 are required to alter endothelial and vascular smooth muscle cell adhesion, proliferation, motility, and survival. As a major platelet protein, for a long time it was postulated to control hemostasis via platelet aggregate stabilization. THSD1 is a potent angiogenesis inhibitor, and down-regulation of THSD1 has been suggested to alter tumor growth by modulating angiogenesis in a variety of tumor types.

Full Name
thrombospondin type 1 domain containing 1
References
  • Lawler J. (2002) Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth. J Cell Mol Med. 6(1): 1-12.
  • Ren B, et al. (2006) Regulation of tumor angiogenesis by thrombospondin-1. Biochim Biophys Acta. 1765(2): 178-88.
  • Mirochnik Y, et al. (2008) Thrombospondin and apoptosis: molecular mechanisms and use for design of complementation treatments. Curr Drug Targets. 9(10): 851-62.
  • Bonnefoy A, et al. (2008) The evolving role of thrombospondin-1 in hemostasis and vascular biology. Cell Mol Life Sci. 65(5): 713-27.
  • Isenberg JS, et al. (2008) Thrombospondin-1: a physiological regulator of nitric oxide signaling. Cell Mol Life Sci. 65(5): 728-42.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-THSD1 Antibody Rabbit Polyclonal ELISA 50400-RP01
    Anti-THSD1 Antibody Rabbit Monoclonal ELISA,ELISA(Cap) 50400-R113
    Anti-THSD1 Antibody Rabbit Monoclonal ELISA 50400-R122
    info info
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