THOP1

THOP1, also known as Thimet oligopeptidase 1, Thimet oligopeptidase, EC 3.4.24.15, or EP24.15, is a zinc(II) endopeptidase implicated in the processing of numerous physiological peptides. As an intracellular enzyme, highly expressed in the brain, kidneys and neuroendocrine tissue, THOP1 has been proposed to metabolize peptides within cells, thereby affecting antigen presentation and G protein-coupled receptor signal transduction. Its substrates is gonadotrophin-releasing hormone (GnRH), an important hypothalamic hormone that regulates the synthesis and release of oestradiol and facilitates female sexual behaviour. THOP1 against toxic effects of Abeta in the early stages of Alzheimer disease (AD) pathology, and suggest that the observed increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta load.

THOP1 Related Areas

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>THOP1

THOP1 Alternative Names

THOP1, EP24.15, MEPD_HUMAN, MP78, TOP [Homo sapiens]

Thop1, AI131655, AI327041, EP24.15 [Mus musculus]

Summaries for THOP1

Wikipedia summary for THOP1:

Thimet oligopeptidase is an enzyme that in humans is encoded by the THOP1 gene.

Human THOP1 Protein General Information

 

• Protein names: Thimet oligopeptidase
  Short name=THOP1
• Sequence length: 689 AA.
• Sequence similarities: Belongs to the peptidase M3 family.
• Subunit structure: Monomer
• Subcellular location: Cytoplasm.
• Cofactor: Binds 1 zinc ion per subunit
• Catalytic activity: Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.

General information above from UniProt

Function for THOP1 Protein

UniProtKB:

THOP1 is involved in the metabolism of neuropeptides under 20 amino acid residues long. THOP1 is involved in cytoplasmic peptide degradation. THOP1 is able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.

Genatlas:

• THOP1 is involved in antigen presentation via MHC class 1
• THOP1 is beta secretase, catalyzing the degradation of somatostatin peptide from APP
• THOP1 is involved in the metabolism of neuropeptides under 20 amino acid residues long
• THOP1 is able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments
• THOP1 plays a major role in degrading proteasome products

Homology for human THOP1

• homolog to rattus metalloendopeptidase 24.15