THOP1 Protein & Antibody

Thimet oligopeptidase 1

THOP1 Products

THOP1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
THOP1	Mouse	THOP1 Protein, Recombinant	50828-M07B

THOP1 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse THOP1	WB, ELISA	THOP1 Antibody	50828-RP02

THOP1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
THOP1	Human	Human THOP1 cDNA Clone / ORF Clone	HG10512-M
THOP1	Mouse	Mouse THOP1 cDNA Clone / ORF Clone	MG50828-G

THOP1 Related Areas

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>THOP1

THOP1 Alternative Names

THOP1, EP24.15, MEPD_HUMAN, MP78, TOP [Homo sapiens]

Thop1, AI131655, AI327041, EP24.15 [Mus musculus]

THOP1 Background

THOP1, also known as Thimet oligopeptidase 1, Thimet oligopeptidase, EC 3.4.24.15, or EP24.15, is a zinc(II) endopeptidase implicated in the processing of numerous physiological peptides. As an intracellular enzyme, highly expressed in the brain, kidneys and neuroendocrine tissue, THOP1 has been proposed to metabolize peptides within cells, thereby affecting antigen presentation and G protein-coupled receptor signal transduction. Its substrates is gonadotrophin-releasing hormone (GnRH), an important hypothalamic hormone that regulates the synthesis and release of oestradiol and facilitates female sexual behaviour. THOP1 against toxic effects of Abeta in the early stages of Alzheimer disease (AD) pathology, and suggest that the observed increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta load.

THOP1 Related Studies

1. Cyr NE, et al. (2010) Nuclear Thimet oligopeptidase is coexpressed with oestrogen receptor alpha in hypothalamic cells and regulated by oestradiol in female mice. J Neuroendocrinol. 22(8): 936-43.
2. Berti DA, et al. (2009) Analysis of intracellular substrates and products of thimet oligopeptidase in human embryonic kidney 293 cells. J Biol Chem. 284(21): 14105-16.
3. Russo LC, et al. (2009) Interaction with calmodulin is important for the secretion of thimet oligopeptidase following stimulation. FEBS J. 276(16): 4358-71.
4. Pollio G, et al. (2008) Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity. Neurobiol Dis. 31(1): 145-58.
5. Bruce LA, et al. (2008) Hydrogen bond residue positioning in the 599-611 loop of thimet oligopeptidase is required for substrate selection. FEBS J. 275(22): 5607-17.