All Thimet Oligopeptidase reagents are produced in house and quality controlled, including 2 Thimet Oligopeptidase Antibody, 30 Thimet Oligopeptidase Gene, 1 Thimet Oligopeptidase IPKit, 1 Thimet Oligopeptidase Lysate, 1 Thimet Oligopeptidase Protein, 2 Thimet Oligopeptidase qPCR. All Thimet Oligopeptidase reagents are ready to use.
Recombinant Thimet Oligopeptidase proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-His.
Thimet Oligopeptidaseantibodies are validated with different applications, which are ELISA, WB, IP.
Thimet OligopeptidasecDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Thimet Oligopeptidase of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Expression host: Baculovirus-Insect Cells
THOP1, also known as Thimet oligopeptidase 1, Thimet oligopeptidase, EC 188.8.131.52, or EP24.15, is a zinc(II) endopeptidase implicated in the processing of numerous physiological peptides. As an intracellular enzyme, highly expressed in the brain, kidneys and neuroendocrine tissue, THOP1 has been proposed to metabolize peptides within cells, thereby affecting antigen presentation and G protein-coupled receptor signal transduction. Its substrates is gonadotrophin-releasing hormone (GnRH), an important hypothalamic hormone that regulates the synthesis and release of oestradiol and facilitates female sexual behaviour. THOP1 against toxic effects of Abeta in the early stages of Alzheimer disease (AD) pathology, and suggest that the observed increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta load.