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TH / Tyrosine Hydroxylase Antibody, Rabbit PAb, Antigen Affinity Purified
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TH / Tyrosine Hydroxylase Antibody, Rabbit PAb, Antigen Affinity Purified PDF Download

Catalog   Size (Price) Quantity In Stock Operation
50997-RP02  

YES   
 

Primary antibody | Secondary antibody | Tag antibody | Isotype control antibody | Loading control antibody | Antibody Purification

TH / Tyrosine Hydroxylase Antibody ( Antigen Affinity Purified ) Datasheet

  Order or Inquire for TH / Tyrosine Hydroxylase Antibody product Quality antibodies Antibody production services
 

TH / Tyrosine Hydroxylase Antibody Product Information

Immunogen :

Recombinant Mouse TH / Tyrosine Hydroxylase protein (Catalog#50997-M07B)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type :

Rabbit IgG

Formulation : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation :

Produced in rabbits immunized with purified, recombinant Mouse TH / Tyrosine Hydroxylase (rM TH / Tyrosine Hydroxylase; Catalog#50997-M07B; P24529; Pro 2-Ser 498). TH / Tyrosine Hydroxylase specific IgG was purified by Mouse TH / Tyrosine Hydroxylase affinity chromatography.

TH / Tyrosine Hydroxylase Antibody Usage Guide

Specificity :

Mouse TH / Tyrosine Hydroxylase

Immunochemistry :

IHC-P: 0.1-2 μg/mL

 

mTH-mouse-brain immunohistochemistry    

Immunochemical staining of mouse TH in mouse brain with rabbit polyclonal antibody (1 μg/mL, formalin-fixed paraffin embedded sections).  
Direct ELISA : This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse TH.
Storage : This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

TH / Tyrosine Hydroxylase Antibody Related Products & Topics

Related Areas:

Enzyme>>Other>>Tyrosine Hydroxylase

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
Tyrosine Hydroxylase Human TH / Tyrosine Hydroxylase Protein, Recombinant 10684-H07B
Tyrosine Hydroxylase Mouse TH / Tyrosine Hydroxylase Protein, Recombinant 50997-M07B

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Mouse Tyrosine Hydroxylase ELISA, IHC-P TH / Tyrosine Hydroxylase Antibody (Antigen Affinity Purified) 50997-RP02

TH / Tyrosine Hydroxylase Antibody Background

Tyrosine Hydroxylase (TH, or TyrH) is the rate-limiting enzyme of catecholamine biosynthesis. Tyrosine Hydroxylase uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its amino terminal 150 amino acids comprise a domain whose structure is involved in regulating the enzyme's activity. The TH enzyme is inhibited in feedback fashion by the catecholamine neurotransmitters. Dopamine binds to Tyrosine Hydroxylase competitively with tetrahydrobiopterin, and interacts with the R domain. Activity of tyrosine hydroxylase is regulated by feedback inhibition and inactivation by catecholamines, and activation by protein phosphorylation. Tyrosine Hydroxylase is modified in the presence of NO, resulting in nitration of tyrosine residues and the glutathionylation of cysteine residues. Tyrosine Hydroxylase involved in the pathogenesis of PD at several different levels, in addition to being a promising candidate for developing new treatments of this disease.

References

  1. Fujisawa H. et al., 2005, Biochem Biophys Res Commun. 338 (1): 271-6.
  2. Daubner SC. et al., 2011, 508 (1): 1-12.
  3. Haavik J. et al., 1998, Mol Neurobiol. 16 (3): 285-309.
 

 

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"