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>Rabbit PAb Antibody
>TH / Tyrosine Hydroxylase Antibody (Antigen Affinity Purified)
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TH / Tyrosine Hydroxylase Antibody ( Antigen Affinity Purified ) Datasheet
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TH / Tyrosine Hydroxylase Antibody Product Information
Recombinant Mouse TH / Tyrosine Hydroxylase protein (Catalog#50997-M07B)
|Antibody Type :||Rabbit Polyclonal Antibody ( Antibody Purification Platform )|
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.|
Produced in rabbits immunized with purified, recombinant Mouse TH / Tyrosine Hydroxylase (rM TH / Tyrosine Hydroxylase; Catalog#50997-M07B; P24529; Pro 2-Ser 498). TH / Tyrosine Hydroxylase specific IgG was purified by Mouse TH / Tyrosine Hydroxylase affinity chromatography.
TH / Tyrosine Hydroxylase Antibody Usage Guide
Mouse TH / Tyrosine Hydroxylase
IHC-P: 0.1-2 μg/mL
|Direct ELISA :||This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse TH.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
TH / Tyrosine Hydroxylase Antibody Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Tyrosine Hydroxylase||Human||TH / Tyrosine Hydroxylase Protein, Recombinant||10684-H07B|
|Tyrosine Hydroxylase||Mouse||TH / Tyrosine Hydroxylase Protein, Recombinant||50997-M07B|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Mouse Tyrosine Hydroxylase||ELISA, IHC-P||TH / Tyrosine Hydroxylase Antibody (Antigen Affinity Purified)||50997-RP02|
TH / Tyrosine Hydroxylase Antibody Background
Tyrosine Hydroxylase (TH, or TyrH) is the rate-limiting enzyme of catecholamine biosynthesis. Tyrosine Hydroxylase uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its amino terminal 150 amino acids comprise a domain whose structure is involved in regulating the enzyme's activity. The TH enzyme is inhibited in feedback fashion by the catecholamine neurotransmitters. Dopamine binds to Tyrosine Hydroxylase competitively with tetrahydrobiopterin, and interacts with the R domain. Activity of tyrosine hydroxylase is regulated by feedback inhibition and inactivation by catecholamines, and activation by protein phosphorylation. Tyrosine Hydroxylase is modified in the presence of NO, resulting in nitration of tyrosine residues and the glutathionylation of cysteine residues. Tyrosine Hydroxylase involved in the pathogenesis of PD at several different levels, in addition to being a promising candidate for developing new treatments of this disease.
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