TGM2 / Transglutaminase 2 Protein & Antibody

TGM2 / Transglutaminase 2 Products

TGM2 / Transglutaminase 2 Protein, Recombinant

Molecule	Species	Description	Cat. No
TGM2/Transglutaminase 2	Human	TGM2/Transglutaminase 2 Protein, Recombinant	11095-H07B

TGM2 / Transglutaminase 2 Antibody

Molecule	Application	Description	Cat. No
Human TGM2/Transglutaminase 2	WB, ELISA	Rabbit Polyclonal Antibody	11095-RP01
Human TGM2/Transglutaminase 2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11095-RP02

TGM2 / Transglutaminase 2 cDNA Clone

Molecule	Species	Description	Cat. No
TGM2/Transglutaminase 2	Human	Homo sapiens TGM2/Transglutaminase 2 cDNA Clone	HG11095-M

TGM2 / Transglutaminase 2 Related Areas

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>Transglutaminase 2/TGM2

TGM2 / Transglutaminase 2 Alternative Names

TGM2, Transglutaminase 2, RP5-1054A22.2, G-ALPHA-h, GNAH, TG2, TGC, C polypeptide, TG(C), TGase C, TGase H, TGase-2, TGase-H [Homo sapiens]

TGM2, Transglutaminase 2, RP23-396G1.2, G[a]h, TG2, TGase2, tTG, tTGas, C polypeptide, OTTMUSP00000016945, TG C, TG(C), TGC, TGase C, TGase-2 [Mus musculus]

TGM2 / Transglutaminase 2 Background

Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth and survival through the anti-apoptosis signaling pathway. It is a calcium-dependent acyltransferase which also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. TGM2 is a multi-functional protein which catalyzes transamidation reactions or acts as a G-protein in intracellular signalling. As an enzyme which is responsible for the majority of transglutaminase (TG) activity in the brain, TGM2 is likely to play a modulatory role in nervous system development and has regulatory effect on neuronal cell death as well. Most importantly, numerous studies have presented data demonstrating that dysregulation of TGM2 may contribute to the pathogenesis of many neurodegenerative disorders, including Huntington's disease, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis as well as nervous system injuries.

TGM2 / Transglutaminase 2 Related Studies

1. Ruan Q, et al. (2007) Transglutaminase 2 in neurodegenerative disorders. Front Biosci. 12: 891-904.
2. Ai L, et al. (2008) The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer. Carcinogenesis. 29(3): 510-8.
3. Filiano AJ, et al. (2010) Transglutaminase 2 protects against ischemic stroke. Neurobiol Dis. 39(3): 334-43.
4. Park D, et al. (2010) Transglutaminase 2: a multi-functional protein in multiple subcellular compartments. Amino Acids. 39(3): 619-31.
5. Miyoshi N, et al. (2010) TGM2 is a novel marker for prognosis and therapeutic target in colorectal cancer. Ann Surg Oncol. 17(4): 967-72.