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TGFBR3 / Betaglycan Protein, Antibody, ELISA Kit, cDNA Clone

TGFBR3 / Betaglycan Related Areas

TGFBR3 / Betaglycan Related Pathways

TGFBR3 / Betaglycan Related Product

TGFBR3 / Betaglycan Summary & Protein Information

TGFBR3 / Betaglycan Related Information

TGFBR3 / Betaglycan Background

Gene Summary: This TGFBR3 locus encodes the transforming growth factor (TGF)-beta type III receptor. TGFBR3 is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this TGFBR3 gene.
General information above from NCBI
Subunit structure: Interacts with TCTEX1D4.
Subcellular location: Secreted. Secreted, extracellular space. Cell membrane; Single-pass type I membrane protein (Potential). Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.
Post-translational: Extensively modified by glycosaminoglycan groups (GAG).
Sequence similarity: Contains 1 ZP domain.
General information above from UniProt

Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. This receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. TGFBR3 is the TGF-β component most commonly downregulated among localized human prostate cancer studies. TGFBR3 knockdown led to focus formation and enhanced expression of CD133, a marker found on prostate cancer stem cells. TGFBR3 is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFβ) and inhibin, two members of the TGFβ superfamily of growth factors that regulate many aspects of reproductive biology. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis.

TGFBR3 / Betaglycan Alternative Name

betaglycan,BGCAN,TGFBR3, [human]
1110036H20Rik,AU015626,AW215636,TBRIII,Tgfbr3, [mouse]

TGFBR3 / Betaglycan Related Studies

  • Johnson DW, et al. (1996) Assignment of human transforming growth factor-beta type I and type III receptor genes (TGFBR1 and TGFBR3) to 9q33-q34 and 1p32-p33, respectively. Genomics. 28 (2): 356-7.
  • Rotzer D, et al. (2001) Type III TGF-beta receptor-independent signalling of TGF-beta2 via T betaRII-B, an alternatively spliced TGF- type II receptor. EMBO J. 20 (3): 480-90.
  • Gao J, et al. (1999) Expression of transforming growth factor-beta receptors types II and III within various cells in the rat periodontium. J Periodont Res. 34 (2): 113-22.
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