All TGFBR3 reagents are produced in house and quality controlled, including 3 TGFBR3 Antibody, 26 TGFBR3 Gene, 2 TGFBR3 Lysate, 2 TGFBR3 Protein, 2 TGFBR3 qPCR. All TGFBR3 reagents are ready to use.
Recombinant TGFBR3 proteins are expressed by HEK293 Cells, Baculovirus-Insect Cells with fusion tags as C-His.
TGFBR3antibodies are validated with different applications, which are ELISA.
TGFBR3cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each TGFBR3 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. This receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. TGFBR3 is the TGF-β component most commonly downregulated among localized human prostate cancer studies. TGFBR3 knockdown led to focus formation and enhanced expression of CD133, a marker found on prostate cancer stem cells. TGFBR3 is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFβ) and inhibin, two members of the TGFβ superfamily of growth factors that regulate many aspects of reproductive biology. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis.