TGFBR3 Protein & Antibody

Transforming growth factor, beta receptor III

TGFBR3 Products

TGFBR3 Protein, Recombinant

Molecule	Species	Description	Cat. No
TGFBR3	Mouse	TGFBR3 Protein, Recombinant	50542-M08H

TGFBR3 Antibody

Molecule	Application	Description	Cat. No
Mouse TGFBR3	WB, ELISA	TGFBR3 Antibody	50542-RP01
Mouse TGFBR3	WB, ELISA	TGFBR3 Antibody (Antigen Affinity Purified)	50542-RP02

TGFBR3 cDNA Clone

Molecule	Species	Description	Cat. No
TGFBR3	Mouse	Mouse TGFBR3 cDNA Clone / ORF Clone	MG50542-M

TGFBR3 Related Areas

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>TGFBR3

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>TGF-beta Family>>TGFBR3

Neuroscience>>Axon Guidance>>TGF-beta Family>>TGFBR3

TGFBR3 Alternative Names

TGFBR3, BGCAN, betaglycan [Homo sapiens]

Tgfbr3, 1110036H20Rik, AU015626, AW215636, TBRIII [Mus musculus]

TGFBR3 Background

Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. This receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. TGFBR3 is the TGF-β component most commonly downregulated among localized human prostate cancer studies. TGFBR3 knockdown led to focus formation and enhanced expression of CD133, a marker found on prostate cancer stem cells. TGFBR3 is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFβ) and inhibin, two members of the TGFβ superfamily of growth factors that regulate many aspects of reproductive biology. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis.

TGFBR3 Related Studies

1. Johnson DW, et al. (1996) Assignment of human transforming growth factor-beta type I and type III receptor genes (TGFBR1 and TGFBR3) to 9q33-q34 and 1p32-p33, respectively. Genomics. 28 (2): 356-7.
2. Rotzer D, et al. (2001) Type III TGF-β receptor-independent signalling of TGF-β2 via TβRII-B, an alternatively spliced TGF-β type II receptor. EMBO J. 20 (3): 480-90.
3. Gao J, et al. (1999) Expression of transforming growth factor-beta receptors types II and III within various cells in the rat periodontium. J Periodont Res. 34 (2): 113-22.