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Rat TGFBR2 Protein (Fc Tag)
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Rat TGFBR2 Protein (Fc Tag) (Cytokine) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
80139-R02H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Transforming growth factor, beta receptor II Protein Datasheet

 

TGFBR2 / TGFβR2 / TGFR2 Protein Price Inquiry ( Available Sizes )

TGFBR2 / TGFβR2 / TGFR2 Protein Product Information

Synonym : TGFBR2
Protein Construction:

A DNA sequence encoding the rat TGFBR2 (P38438) (Met1-Gln166) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Source: Rat
Expression Host: Human Cells

TGFBR2 / TGFβR2 / TGFR2 Protein QC Testing

Purity: > 95% as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

TGFBR2 / TGFβR2 / TGFR2 protein

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Ile 24
Molecular Mass:

The recombinant rat TGFBR2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 384 amino acids and has a predicted molecular mass of 43 kDa. The apparent molecular mass of the protein is approximately 54 kDa in SDS-PAGE under reducing conditions.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

TGFBR2 / TGFβR2 / TGFR2 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TGFBR2 / TGFβR2 / TGFR2 Protein Related Products & Topics

TGFBR2 / TGFβR2 / TGFR2 Protein Description

The type I I receptor for transforming growth factor-beta (TGFβ R2) is a member of the serine/threonine protein kinase family and the TGF-β receptor subfamily. This membrane-bound glyvoprotein contains a cysteine-rich extracellular domain, a single hydrophobic transmembrane domain, and a cytoplasmic serine/threonine kinase domain. TGFR2 binds TGF-β1 and TGF-β3 with high affinity and TGF-β2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I  receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. It has been shown that TGFR2 kinase is regulated intricately by autophosphorylation on different serine residues and affects signal transduction both positively and negatively. Aberrant expression or mutation of this gene is associated with tumorogenesis and progression, as well as the Marfan Syndrome and Loeys-Deitz Aortic Aneurysm Syndrome.

References

  1. G Lin, H.Y. et al., 1992, Cell. 68: 775-785.
  2. Lawler, S. et al., 1997, J. Biol. Chem. 272: 14850-14859.
  3. Luo, K. et al., 1997, EMBO. J. 16: 1970-1981.
  4. Moustakas, A. et al., 2001, J. Cell. Sci. 114: 4359-4369.
  5. Law, C. et al., 2006, J. Med. Genet. 43: 908-916.
 

All TGF-beta Proteins

Product name Product name
ACVR2B / ActivinR-IIB Protein ALK4 / ACVR1B Protein
ALK-2 / ACVR1 ProteinMouse GDF10 / BMP-3B Protein (Fc Tag)
ACVR2 / ACTRII / ACVR2A ProteinMouse Activin A Protein (His Tag)
BMP-2 ProteinTGFB2 / TGF-beta 2 Protein (Latent) (His Tag)
BMP-5 ProteinMouse TGFBR3 / Betaglycan Protein (His Tag)
BMPRIA / ALK-3 / CD292 ProteinATF2 Protein (GST Tag)
BMPR-II ProteinALK-2 / ACVR1 / ALK2 Protein (His Tag)
Endoglin / CD105 / ENG ProteinHuman / Rhesus / Canine TGFβ1 / TGFB1 Protein (Native)
TGFβR2 / TGFR2 ProteinRat TDGF1 / CRGF Protein
Mouse ALK-3 / BMPR1A ProteinBMPR1B / ALK6 (149-502) Protein (GST Tag)
Lefty A ProteinRat TGFBR2 Protein
Mouse ACVR2B ProteinCynomolgus ACVR1B / ALK-4 Protein
ACVR2B / ActivinR-IIB Protein (His Tag)Rat ALK-2 / ACVR1 / ALK2 Protein
BMPR-II Protein (His Tag)Cynomolgus TGFBR2 Protein
GDF-15 ProteinCynomolgus ALK-7 / ALK7 / ACVR1C Protein
Mouse ALK-2 / ACVR1 ProteinCynomolgus ALK-2 / ACVR1 / ALK2 Protein
Activin A Protein (His Tag)TGFBR1 / ALK-5 / SKR4 (aa 200-503) Protein (GST Tag)
latent TGFβ1 Protein (His Tag)Danio rerio (zebrafish) BMP-2 / BMP2A Protein (Native)
BMP-2 / BMP2A Protein (Native)Rat ACVR1B / ALK-4 Protein
Activin B Protein (His Tag)BMPR1B / ALK6 Protein
TGFB1 / TGF-beta1 Protein (Native)TGFBR3 / Betaglycan Protein (His Tag)
Mouse ACTRIIB / ACVR2B Protein (His Tag)Canine ALK-2 / ACVR1 / ALK2 Protein
ALK4 / ACVR1B Protein (His Tag)Canine ALK-2 / ACVR1 / ALK2 Protein (His Tag)
TGFBR1 / ALK-5 / SKR4 ProteinCanine GFRA1 / GFR alpha-1 Protein (His Tag)
Mouse ALK-3 / BMPR1A Protein (His Tag)Rat GFRA1 / GFR alpha-1 Protein
Endoglin / CD105 / ENG Protein (His Tag)Cynomolgus ACVR2B / ACTRIIB Protein (His Tag)
TDGF1 / CRGF Protein (His Tag)Rat NCAM1 / CD56 Protein (His Tag)
Mouse ACVR2A / ActrIIa Protein (His Tag)Mouse GFRA3 / GFR-alpha-3 Protein (His Tag)
Mouse ACVR2A / ActrIIa ProteinRat TDGF1 / CRGF Protein (His Tag)
Mouse Endoglin / ENG / CD105 Protein (His Tag)Cynomolgus ACVR2B / ACTRIIB Protein
Mouse MSTN / GDF8 ProteinRat TGFβ1 / TGFB1 Protein (His Tag)
ACVR2 / ACTRII / ACVR2A Protein (His Tag)Cynomolgus ACVR2B / ACTRIIB Protein
BMPRIA / ALK-3 / CD292 Protein (His Tag)Mouse TGFβ1 / TGFB1 Protein (His Tag)

All TGF-beta Antibodies

Product name Product name
BMPR2 / BMPR-II / PPH1 Antibody ALK-3 / BMPR-1A / CD292 Antibody (Antigen Affinity Purified)
BMPR2 / BMPR-II / PPH1 Antibody (Antigen Affinity Purified)Endoglin / CD105 / ENG Antibody
TGF-beta1 / TGFB1 AntibodyEndoglin / CD105 Antibody ( FITC )
TGF-beta1 / TGFB1 Antibody (Antigen Affinity Purified)Endoglin / CD105 Antibody ( FITC )
TGF-beta1 / TGFB1 Antibody (Mouse Monoclonal Antibody)Endoglin / CD105 / ENG Antibody
TGF-beta1 / TGFB1 AntibodyTGF-beta 1 Antibody
ACVR2B / ACTRIIB AntibodyBMP-2 Antibody
ACVR2B / ACTRIIB Antibody (Antigen Affinity Purified)Endoglin / CD105 Antibody
Endoglin / CD105 / ENG AntibodyACVR2B / ACTRIIB Antibody
Endoglin / CD105 / ENG Antibody (Antigen Affinity Purified)ACVR2A Antibody
ACVR1B / ALK4 AntibodyACVR2A Antibody (Antigen Affinity Purified)
Endoglin / ENG / CD105 AntibodyTGFBR3 Antibody
Endoglin / ENG / CD105 Antibody (Antigen Affinity Purified)TGFBR3 Antibody (Antigen Affinity Purified)
Endoglin / CD105 / ENG AntibodyALK-3 / BMPRIA Antibody
Endoglin / CD105 / ENG AntibodyBMP-7 Antibody
BMPR2 / BMPR-II / PPH1 AntibodyInhibin beta A / INHBA Antibody
ACVR2B / ACTRIIB AntibodyGFRA1 Antibody
ALK-3 / BMPR-1A / CD292 AntibodyTGFBR3 Antibody
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"