- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
>Human Cell Expressed
>Cynomolgus TGFBR2 Protein (Fc Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Transforming growth factor, beta receptor II (70/80kDa) Protein Datasheet
TGFBR2 / TGF beta-2 / TGFB2 Protein Price Inquiry ( Available Sizes )
TGFBR2 / TGF beta-2 / TGFB2 Protein Product Information
A DNA sequence encoding the cynomolgus TGFBR2 (F6Q1B1) (Met1-Arg159) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
TGFBR2 / TGF beta-2 / TGFB2 Protein QC Testing
|Purity:||> 95 % as determined by SDS-PAGE||SDS-PAGE:
TGFBR2 / TGF beta-2 / TGFB2 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Ile 24|
The recombinant cynomolgus TGFBR2 is a disulfide-linked homodimer. The reduced monomer comprises 377 amino acids and has a calculated molecular mass of 42.4 KDa.The apparent molecular mass of cynomolgus CD38 is approximately 56-62 KDa respectively in SDS-PAGE.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
TGFBR2 / TGF beta-2 / TGFB2 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
TGFBR2 / TGF beta-2 / TGFB2 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|TGF-beta 2||Human||TGF-beta 2 Protein, Recombinant, Latent||10382-H08H|
|TGF-beta 2||Rat||TGFBR2 / TGF beta-2 / TGFB2 Protein, Recombinant||80139-R02H|
|TGF-beta 2||Cynomolgus||TGFBR2 / TGF beta-2 / TGFB2 Protein, Recombinant||90063-C02H|
TGFBR2 / TGF beta-2 / TGFB2 Protein Description
Transforming growth factor beta 2 (TGF beta 2), a member of the TGF-beta family, is a secreted protein known as a cytokine that performs many cellular functions. TGF beta 2 has a vital role during embryonic development. In the early avian embryo TGF beta 2 has a major role in the retinoic acid-regulated posterior heart morphogenesis for which it does not use Smad2/3 pathways, but may use other signaling pathways. TGF beta 2 induces senescence-associated trabecular meshwork (TM) changes and activates the senescence-related p16-pRb signal transduction pathway in vitro. Thus, minimizing TGF beta 2 levels may help to prevent the ageing process in the TM as seen in primary open angle glaucoma (POAG). TGF beta 2 suppresses proliferation of epithelial cells and stimulates synthesis of certain caspases. Then TGF beta 2 triggers the intrinsic caspase network and subsequently epithelial cells are eliminated through apoptotic cell death. The increased levels of TGF beta 2 triggered a neuronal cell death pathway related to Alzheimer's disease (AD) by binding to the extracellular domain of amyloid beta precursor protein (APP). The upregulation of the TGF beta 2 level is a common pathological feature of AD brains and suggests that it may be closely linked to the development of neuronal death related to AD. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy.
- Ghatpande SK. et al., 2010, Dev Growth Differ. 52 (5): 433-55.
- Yu AL. et al., 2010, Invest Ophthalmol Vis Sci. 51 (11): 5718-23.
- Hibino T. et al., 2004, J Dermatol Sci. 35 (1): 9-18.
- Noguchi A. et al., 2010, Int J Neurosci. 120 (3): 168-75.
- Schlingensiepen KH. et al., 2006, Cytokine Growth Factor Rev. 17 (1-2): 129-39.
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