TGFBR2 Protein

Transforming Growth Factor, Beta Receptor II

TGFBR2 Products

TGFBR2 Protein, Recombinant

Molecule	Species	Description	Cat. No
TGFBR2	Human	TGFBR2/Fc Protein, Recombinant	10358-H03H

  10358-H03H:  The ED₅₀ for this effect is typically 1.85 µg/mL in the presence of 1 ng/mL of recombinant human TGF-beta1. Measured by its ability to inhibit TGF-beta1 activity on Mv-1-lu mink lung epithelial cells .

TGFBR2 cDNA Clone

Molecule	Species	Description	Cat. No
TGFBR2	Human	TGFβR2 transcript variant 2 cDNA Clone / ORF Clone	HG10358-M
TGFBR2	Rat	TGFBR2 transcript variant 2 cDNA Clone	RG80139-G
TGFBR2	Cynomolgus	TGFBR2 cDNA Clone / ORF Clone	KG90063-G

TGFBR2 Related Areas

Neuroscience>>Axon Guidance>>TGF-beta Family>>TGFBR2

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>TGF-beta Family>>TGFBR2

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>TGFBR2

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>TGFBR2

TGFBR2 Alternative Names

TGFBR2, TGFR-2, MFS2, TGFbeta-RII, AAT3, FAA3, LDS1B, LDS2B, RIIC, TAAD2 [Homo sapiens]

Tgfbr2, TBR-II, TbetaR-II, TbetaRII, 1110020H15Rik, AU042018, DNIIR, RIIDN, [Mus musculus]

TGFBR2 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
TGF-beta 1	Human	Latent TGF-beta 1 protein, Recombinant
ALK-1/ACVRL1	Human	ALK-1/ACVRL1/Fc Protein, Recombinant
ALK-1/ACVRL1	Human	ALK-1/ACVRL1 Protein, Recombinant
ALK-1/ACVRL1	Mouse	ALK-1/ACVRL1/Fc Protein, Recombinant
Endoglin/CD105	Human	Endoglin/CD105/Fc Protein, Recombinant
Decorin	Human	Decorin/Fc Protein, Recombinant

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
TGF-beta 1	Human	Homo sapiens TGF-beta 1 cDNA Clone(NM_000660.3)
TGF-beta 2	Human	Homo sapiens TGF-beta2 transcript variant 2 cDNA Clone(NM_003238.2)
TGF-beta 3	Human	Homo sapiens TGF-beta 3 cDNA Clone(NM_003239.2)
ALK-1/ACVRL1	Human	Homo sapiens ALK-1/ACVRL1 transcript variant 1 cDNA Clone(NM_000020.2)
ALK-7	Human	Homo sapiens ALK-7 cDNA Clone(NM_145259.2)
Cripto/TDGF1	Human	Homo sapiens Cripto/TDGF1 cDNA Clone(NM_003212.2)
Endoglin/CD105	Human	Homo sapiens Endoglin/CD105 transcript variant 1 cDNA Clone(NM_001114753.1)
TGFBR1/ALK-5	Human	Homo sapiens TGFBR1/ALK-5 cDNA Clone(NM_004612.2)
BAMBI/NMA	Human	Homo sapiens BAMBI/NMA cDNA Clone(NM_012342.2)
Smad1	Human	Homo sapiens Smad1 cDNA Clone(NM_001003688.1)
Smad2	Human	Homo sapiens Smad2 transcript variant 2 cDNA Clone(NM_001003652.2)
Smad3	Human	Homo sapiens Smad3 cDNA Clone(NM_005902.3)
Smad5	Human	Homo sapiens Smad5 transcript variant 3 cDNA Clone(NM_001001420.1)

TGFBR2 Background

TGFBR2 is member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised by a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets. TGFBR2 has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is increased in oral squamous cell carcinoma cells. Its expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity of tamoxifen metabolites in breast cancer.

TGFBR2 Related Studies

1. Yu Y, et al. (2012) MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFβR2) in colon cancer cells. Carcinogenesis. 33(1):68-76.
2. Shima K, et al. (2011) TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers. PLoS One. 6(9):e25062.
3. Biros E, et al. (2011) Meta-analysis of the association between single nucleotide polymorphisms in TGF-β receptor genes and abdominal aortic aneurysm. Atherosclerosis. 219(1):218-23.