TGFBI Protein (BIGH3 Protein)

Transforming Growth Factor, Beta-Induced

TGFBI Products

TGFBI Protein, Recombinant

Molecule	Species	Description	Cat. No
TGFBI/BIGH3	Human	TGFBI/BIGH3 Protein, Recombinant	10569-H08H

TGFBI cDNA Clone

Molecule	Species	Description	Cat. No
TGFBI/BIGH3	Human	Homo sapiens TGFBI/BIGH3 cDNA Clone(NM_000358.2)	HG10569-M

TGFBI Related Areas

Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>TGFBI/BIGH3

TGFBI Alternative Names

TGFBI, BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1 [Homo sapiens]

Tgfbi, big-h3, 68kDa, AI181842, AI747162, Beta-ig, MGC150270 [Mus musculus]

TGFBI Background

TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. TGFBI plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. TGFBI is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in TGFBI are associated with multiple types of corneal dystrophy. TGFBI can bind to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, TGFBI may be involved in endochondral bone formation. Loss of the TGFBI is sufficient to induce specific resistance to paclitaxel and mitotic spindle abnormalities in ovarian cancer cells. Paclitaxel-resistant cells treated with recombinant TGFBI protein show integrin-dependent restoration of paclitaxel sensitivity via FAK- and Rho-dependent stabilization of microtubules. Immunohistochemical staining for TGFBI in paclitaxel-treated ovarian cancers from a prospective clinical trial showed that morphological changes of paclitaxel-induced cytotoxicity were restricted to areas of strong expression of TGFBI.

TGFBI Related Studies

1. Ahmed AA, et al. (2007) The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. Cancer Cell. 12(6): 514-27.
2. Kannabiran C, et al. (2006) TGFBI gene mutations in corneal dystrophies. Hum Mutat. 27(7): 615-25.