TGF beta 2 Protein, Canine, Recombinant (His Tag)

Cat: 70099-D08H
Contact us:
+86-400-890-9989
order@sinobiological.com
Distributors
All TGF beta 2 Reagents
CRO Services
Product recommended

All TGF beta 2 Reagents
TGF beta 2 Protein, Canine, Recombinant (His Tag) Product Information
Purity
> (32+46+17) % as determined by SDS-PAGE.
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the canine TGFB2 (XP_858677.1) (Met1-Ser414) was expressed with a polyhistidine tag at the C-terminus.
Reference#
Expressed Host
HEK293 Cells
Species
Canine
Predicted N Terminal
Leu 21
Molecule Mass
The recombinant canine TGFB2 consists 405 amino acids and predicts a molecular mass of 47 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
TGF beta 2 Protein, Canine, Recombinant (His Tag) in SDS-PAGE
Canine TGF-beta 2 Protein 12285
TGF beta 2 Protein, Canine, Recombinant (His Tag) Alternative Names
TGF-beta 2 Protein, Canine;TGFB2 Protein, Canine
TGF beta 2 Background Information

TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Silencing Smad2 and Smad3 efficiently blocked the effect of TGF beta 2 on cell proliferation, migration, and extracellular matrix production. TGF beta 2 activation of MEKK3/ERK1/2/5 signaling modulates Has2 expression and hyaluronan (HA) production leading to the induction of epithelial to mesenchymal transformation (EMT) events. In addition, the upregulation of the TGF beta 2 level is a common pathological feature of Alzheimer's disease (AD) brains and suggests that it may be closely linked to the development of neuronal death related to AD.

Full Name
transforming growth factor beta 2
References
  • Schlingensiepen KH, et al. (2006) Targeted tumor therapy with the TGF-beta 2 antisense compound AP 12009. Cytokine Growth Factor Rev. 17(1-2): 129-39.
  • Ghatpande SK, et al. (2010) Transforming growth factor beta2 is negatively regulated by endogenous retinoic acid during early heart morphogenesis. Dev Growth Differ. 52(5): 433-55.
  • Noguchi A, et al. (2010) Transforming growth factor beta2 level is elevated in neurons of Alzheimer's disease brains. Int J Neurosci. 120(3): 168-75.
  • Li J, et al. (2011) Comparative effects of TGF-_2/Smad2 and TGF-_2/Smad3 signaling pathways on proliferation, migration, and extracellular matrix production in a human lens cell line. Exp Eye Res. 92(3): 173-9.
  • Other TGF beta 2 Proteins

    Rhesus TGF beta 2 Proteins

    Product Name Cat.No.
    TGF beta 2 Protein, Rhesus, Recombinant (His Tag) 90036-K08H

    Mouse TGF beta 2 Proteins

    Product Name Cat.No.
    TGF beta 2 Protein, Mouse, Recombinant (His Tag) 50153-M08H
    info info
    添加购物车成功! 添加购物车失败!