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TGFB1 Protein, Antibody, ELISA Kit, cDNA Clone

TGFB1 Protein, Antibody, ELISA Kit, cDNA Clone Products

With multiple advanced technology platforms and large scale capacities, Sino Biological has quickly emerging as a leader of life science research tool developer worldwide. All our proteins are manufactured in bulk quantities using sequence verified vectors and state-of-the-art mammalian, insect, or E. coli expression processes. We are adding more than 800 proteins per year, of which "hot" proteins are high on the priority list, such as H1N1 antigens and antibodies that we offered.

Sino Biological Inc offers quality TGFB1 Protein, Antibody, ELISA Kit, cDNA Clone Products for research .

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TGFB1 Protein, Antibody, ELISA Kit, cDNA Clone

TGFB1 Products

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Summary of TGFB1 Protein, Antibody, ELISA Kit, cDNA Clone

TGFB1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGFB1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGFB1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGFB1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGFB1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGFB1 also has the opposite effect on cells of myeloid origin. TGFB1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.

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