Transforming Growth Factor Beta (TGF-beta) Family

Transforming Growth Factor Beta (TGF-beta) Superfamily Products Index

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TGF-beta Superfamily
Activin/Inhibin	TGF-beta Family
BMP (Bone Morphogenetic Protein) Family	TGF-beta Superfamily Modulators
GDF (Growth Differentiation Factor) Family	TGF-beta Superfamily Receptors
GDNF (Glial cell line-Derived Neurotrophic Factor) Family	Other TGF-beta Superfamily Ligands
TGF-beta Signaling Pathways

Transforming Growth Factor Beta (TGF-beta) Family Products

Product Categories / Species	Human	Mouse	Rat
Recombinant Proteins	13	3	1
Antibodies	17	2	-
ELISA Kit	1	-	-
ORF cDNA Clones	16	11	1

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_* Being developed. Tell us your requirement so that the products of interest be placed on the priority list.

TGF-beta Family Ligands

TGF-beta 1

TGF-beta 2

TGF-beta 3 ^*

TGF-beta Family Receptors

ALK-1 / ACVRL1	Endoglin / CD105	TGFBR2
ALK-7^*	TGFBR1 / ALK-5	TGFBR3
Cripto / TDGF1

TGF-beta Family Modulators

BAMBI / NMA	Smad2^*	Smad5^*
Decorin	Smad3^*	ATF2
Smad1^*	Smad4^*

Transforming Growth Factor Beta (TGF-beta) Family Background

Transforming growth factor-beta 1 (TGF-beta 1), originally described in 1983, is the first member of the TGF-beta family. A number of closely related proteins designated TGF-beta 2-5 has been recognized. Since then, TGF-beta has been found to have a plethora of effects, such as regulation of cell growth, proliferation, differentiation, adhesion, migration, and apoptosis. Recent findings indicate that TGF-beta and other morphogens, such as BMP and Hedgehog, also serve as axon guidance molecules during development of the nervous system. TGF-beta's dual role as a tumor suppressor and promoter has also been discovered.

Transforming Growth Factor Beta (TGF-beta) Family Related Studies

Massagué J. (1998) TGF-beta signal transduction. Annu Rev Biochem. 67:753-91.
Massague J. (2000) How cells read TGF-beta signals. Nat Rev Mol Cell Biol. 1: 169–78.
Charron F, et al. (2007) The Hedgehog, TGF-beta/BMP and Wnt families of morphogens in axon guidance. Adv Exp Med Biol. 621:116-33.
Garber K. (2009) Companies waver in efforts to target transforming growth factor beta in cancer. J Natl Cancer Inst. 101(24):1664-7.
Das J, et al. (2009) Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med. 206(11):2407-16.

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