TGF-beta 2 Protein (TGFB2 Protein)

Transforming Growth Factor, beta 2

TGF-beta 2 Products

TGF-beta 2 Protein, Recombinant

Molecule	Species	Description	Cat. No
TGF-beta 2	Human	TGF-beta 2 Protein, Recombinant, Latent	10382-H08H

TGF-beta 2 cDNA Clone

Molecule	Species	Description	Cat. No
TGF-beta 2	Human	TGF-beta2 transcript variant 2 cDNA Clone / ORF Clone	HG10382-M
TGF-beta 2	Mouse	TGF-beta2 cDNA Clone / ORF Clone	MG50153-M
TGF-beta 2	Rat	TGFB2 cDNA Clone / ORF Clone	RG80119-G
TGF-beta 2	Cynomolgus	TGFB2 cDNA Clone / ORF Clone	KG90036-G

TGF-beta 2 Related Areas

Cancer>>Cancer Biomarkers>>TGF-beta 2

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>TGF-beta Family>>TGF-beta 2

Neuroscience>>Axon Guidance>>TGF-beta Family>>TGF-beta 2

TGF-beta 2 Alternative Names

TGF-beta 2, TGFB2, MGC116892, TGF-beta2 [Homo sapiens]

TGF-beta 2, Tgfb2, BB105277, Tgf-beta2, Tgfb-2 [Mus musculus]

TGF-beta 2 Background

TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Silencing Smad2 and Smad3 efficiently blocked the effect of TGF beta 2 on cell proliferation, migration, and extracellular matrix production. TGF beta 2 activation of MEKK3/ERK1/2/5 signaling modulates Has2 expression and hyaluronan (HA) production leading to the induction of epithelial to mesenchymal transformation (EMT) events. In addition, the upregulation of the TGF beta 2 level is a common pathological feature of Alzheimer's disease (AD) brains and suggests that it may be closely linked to the development of neuronal death related to AD.

TGF-beta 2 Related Studies

1. Schlingensiepen KH, et al. (2006) Targeted tumor therapy with the TGF-beta 2 antisense compound AP 12009. Cytokine Growth Factor Rev. 17(1-2): 129-39.
2. Ghatpande SK, et al. (2010) Transforming growth factor beta2 is negatively regulated by endogenous retinoic acid during early heart morphogenesis. Dev Growth Differ. 52(5): 433-55.
3. Noguchi A, et al. (2010) Transforming growth factor beta2 level is elevated in neurons of Alzheimer's disease brains. Int J Neurosci. 120(3): 168-75.
4. Li J, et al. (2011) Comparative effects of TGF-_2/Smad2 and TGF-_2/Smad3 signaling pathways on proliferation, migration, and extracellular matrix production in a human lens cell line. Exp Eye Res. 92(3): 173-9.