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TGF-beta 1 (TGFB1) Protein, Antibody, Gene & Cell Lysate

  • TGFB1 Protein
  • TGFB1 Antibody
  • TGFB1 Gene
  • TGFB1 Cell Lysate

TGF-beta 1 Protein (TGFB1 Protein)

Human TGF-beta 1 Protein

Latent TGF-beta 1 protein (10804-H08H)   Activity assay
 
Tag: his
Expression host: Human Cells
Price/Size: $420 / 20µgorder   SDS-PAGE
 
Human / Rhesus / Canine TGF-beta 1 Protein (active) (10804-HNAC) Activity assay
 
Tag: untagged
Expression host: CHO Stable Cells
Price/Size: $190 / 20µgorder SDS-PAGE

Rat TGF-beta 1 Protein

Rat TGF-beta 1 Protein (80116-R08H)   Activity assay
 
Tag: his
Expression host: Human Cells
Price/Size: $190 / 20µgorder   SDS-PAGE

TGF-beta 1 Antibody (TGFB1 Antibody)

Anti Human TGF-beta 1 Antibody

Anti Human TGF-beta1 / TGFB1 Antibody (10804-MM03)
 
Host & Clone: Mouse mAb
Application: WB
Price/Size: $230 / 100µgorder
 
Anti Human TGF-beta1 / TGFB1 Antibody (10804-MM06)
 
Host & Clone: Mouse mAb
Application: ELISA
Price/Size: $230 / 100µgorder
 
Anti Human TGF-beta1 / TGFB1 Antibody (10804-RP01)
 
Host & Clone: Rabbit pAb
Application: WB, ELISA
Price/Size: $135 / 100µgorder
 
Anti Human TGF-beta1 / TGFB1 Antibody (Antigen Affinity Purified) (10804-RP02)
 
Host & Clone: Rabbit pAb
Application: ELISA
Price/Size: $290 / 100µgorder

TGF-beta 1 Gene (TGFB1 Gene)

Human TGF-beta 1 Gene

Human TGF-beta 1 Gene cDNA Clone / ORF Clone (HG10804-M)
 
cDNA size: 1173bp order
Price (Cloning Vector): $95 (pMD18-T Simple Vector)
Price (Expression Vector): $295  (pCMV / hygro)
$295 (pCMV / hygro - HA)
$295 (pCMV / hygro - His)
$295 (pCMV / hygro - Myc)
$295 (pCMV / hygro - FLAG)
 
Human TGF-beta 1 ORF Expression Clone, His-tagged (HG10804-M-H)
 
cDNA size: 1206bp order
Expression Vector: pCMV/hygro-His
Price: $295
 
Human TGF-beta 1 ORF Expression Clone, HA-tagged (HG10804-M-Y )
 
cDNA size: 1203bp order
Expression Vector: pCMV / hygro - HA
Price: $295
 
Human TGF-beta 1 ORF Expression Clone, Myc-tagged (HG10804-M-M )
 
cDNA size: 1203p order
Expression Vector:pCMV / hygro - Myc
Price: $295 
 
Human TGF-beta 1 ORF Expression Clone, FLAG-tagged (HG10804-M-F)
 
cDNA size: 1200bp order
Expression Vector: pCMV / hygro-Flag
Price: $295

Mouse TGF-beta 1 Gene

Mouse TGFB1 Gene cDNA Clone / ORF Clone (HG10804-M-M)
 
cDNA size: 1173bp order
Price (Cloning Vector): $95 (pMD19-T Simple Vector)
Price (Expression Vector): $295  (pCMV / hygro)
$295 (pCMV / hygro - HA)
$295 (pCMV / hygro - His)
$295 (pCMV / hygro - Myc)
$295 (pCMV / hygro - FLAG)

Rat TGF-beta 1 Gene

Rat TGFB1 Gene cDNA Clone / ORF Clone (RG80116-G )
 
cDNA size: 1173bp order
Price (Cloning Vector): $95 (pGEM-T Vector)
Price (Expression Vector): $295  (pCMV / hygro)
$295 (pCMV / hygro - HA)
$295 (pCMV / hygro - His)
$295 (pCMV / hygro - Myc)
$295 (pCMV / hygro - FLAG)

Canine TGF-beta 1 Gene

Canine TNFa Gene cDNA Clone / ORF Clone (DG70087-G )
 
cDNA size: 1173bp order
Price (Cloning Vector): $95 (pGEM-T Vector)
Price (Expression Vector): $295  (pCMV / hygro)
$295 (pCMV / hygro - HA)
$295 (pCMV / hygro - His)
$295 (pCMV / hygro - Myc)
$295 (pCMV / hygro - FLAG)

TGF-beta 1 Cell Lysate (TGFB1 Cell Lysate)

Human TGF-beta 1 Cell Lysate

Human latent TGFβ1 Human Cells Transfected Lysate (positive control) (denatured) (10804-H08HL)
 
Expressed Host: Human Cells
Application: WB
Price/Size: $195 / 300µgorder
 
Human / Rhesus / Canine TGFβ1 / TGFB1 CHO Transfected Lysate (positive control) (denatured) (10804-HNACL)
 
Expressed Host: CHO Cells
Application: WB
Price/Size: $195 / 300µgorder

Rat TGF-beta 1 Cell Lysate

Rat TGFβ1 / TGFB1 Human Cells Transfected Lysate (positive control) (denatured) (80116-R08HL)
 
Expressed Host: Human Cells
Application: WB
Price/Size: $195 / 300µgorder

 

TGF-beta 1 / TGFB1 Related Areas

Neuroscience>>Axon Guidance>>TGF-beta Family>>TGF-beta 1

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Cell Lineage Marker>>TGF-beta 1

Cancer>>Cancer Biomarkers>>TGF-beta 1

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>TGF-beta Family>>TGF-beta 1

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>TGF-beta 1

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Family>>TGF-beta 1

TGF-beta 1 Alternative Names

TGFB1, TGFB, TGFbeta, CED, DPD1, LAP [Homo sapiens]

TGF-beta 1, Tgfb1, TGFbeta1, Tgfb, Tgfb-1 [Mus musculus]

What is TGF-beta

TGF-beta (Transforming growth factor beta / TGF-β) protein is a type of cytokine that controls proliferation, cellular differentiation, and other functions in most cells. TGF-beta, is a protein synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta protein has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. Learn more.

TGF-beta Structure and Function

The three isoforms of TGF-beta, TGF-beta 1, TGF-beta 2, TGF-beta 3, were first identified from three peaks of activity seen during some of the earliest attempts to purify TGF-beta. The N-linked glycosylation sites, nine cysteine residues, the hydrophobic dimer interface and the protein backbone are highly conserved features across all three isoforms. TGF-beta family members play central roles in metazoan developmental processes, including initiation of appendage formation in adult flies, establishment of the mammalian left-right body plane, and regulation of nematode morphology. Learn more.

TGF-beta Signaling Pathway

TGF-beta signaling is involved in the regulation of proliferation, differentiation and survival/or apoptosis of many cells, including glioma cells. TGF-beta protein acts via specific receptors activating multiple intracellular pathways resulting in phosphorylation of receptor-regulated Smad2/3 proteins that associate with the common mediator, Smad4. Such complex translocates to the nucleus, binds to DNA and regulates transcription of many genes. Furthermore, TGF-beta -activated kinase-1 (TAK1) is a component of TGF-beta signaling and activates mitogen-activated protein kinase cascades. Learn more.

TGF-beta Receptor

TGF-beta receptors are single pass serine/threonine kinase receptors. They exist in several different isoforms that can be homo- or heterodimeric. TGF-beta signaling is initiated by binding of the growth factor ligand to the small extracellular domains of two homologous, functionally distinct transmembrane receptor kinases: the TGF-beta receptor 1 and TGF-beta receptor 2 (TbetaR1 and TbetaR2, respectively). Learn more.

TGF-beta 1 / TGFB1 Related Studies

  1. Khalil N. (1999). TGF-beta: from latent to active. Microbes Infect. 1 (15): 1255–63.
  2. The TGF-beta system — Nature Reviews Molecular Cell Biology.
  3. Hinck, A.P, et al. (1996) Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2. Biochemistry. 35: 8517-8534.
  4. Heldin CH, et al. (1997) TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature. 390(6659):465-71.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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