TGF-beta 1 Protein & Antibody (TGFB1)

Transforming Growth Factor, beta 1

TGF-beta 1 Products

TGF-beta 1 Protein, Recombinant

Molecule	Species	Description	Cat. No
TGF-beta 1	Human	Latent TGF-beta 1 protein, Recombinant	10804-H08H
TGF-beta 1	Human	TGF-beta 1 Protein, Recombinant, Native	10804-HNAH
TGF-beta 1	Human	TGFβ1 / TGFB1 Protein, Recombinant, Native	10804-HNAC

  10804-HNAH:  IC₅₀ = 0.04 - 0.2 ng / ml. Measured by its ability to inhibit cell proliferation of Mv-1-lu mink lung epithelial cells.

TGF-beta 1 Antibody

Molecule	Application	Description	Cat. No
Human TGF-beta 1	WB	Mouse Monoclonal Antibody	10804-MM03
Human TGF-beta 1	ELISA	Mouse Monoclonal Antibody	10804-MM06
Human TGF-beta 1	WB, ELISA	Rabbit Polyclonal Antibody	10804-RP01
Human TGF-beta 1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10804-RP02
Human TGF-beta 1	WB, ELISA	Rabbit Monoclonal Antibody	10804-R016

TGF-beta 1 cDNA Clone

Molecule	Species	Description	Cat. No
TGF-beta 1	Human	TGF-beta 1 cDNA Clone(NM_000660.3)	HG10804-M
TGF-beta 1	Mouse	TGF-beta 1 cDNA Clone / ORF Clone	MG50698-M
TGF-beta 1	Rat	TGFB1 cDNA Clone / ORF Clone	RG80116-G

TGF-beta 1 Related Areas

Neuroscience>>Axon Guidance>>TGF-beta Family>>TGF-beta 1

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Cell Lineage Marker>>TGF-beta 1

Cancer>>Cancer Biomarkers>>TGF-beta 1

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>TGF-beta Family>>TGF-beta 1

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>TGF-beta 1

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Family>>TGF-beta 1

TGF-beta 1 Alternative Names

TGFB1, TGFB, TGFbeta, CED, DPD1, LAP [Homo sapiens]

TGF-beta 1, Tgfb1, TGFbeta1, Tgfb, Tgfb-1 [Mus musculus]

TGF-beta 1 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
ALK-1/ACVRL1	Human	ALK-1/ACVRL1/Fc Protein, Recombinant
ALK-1/ACVRL1	Human	ALK-1/ACVRL1 Protein, Recombinant
ALK-1/ACVRL1	Mouse	ALK-1/ACVRL1/Fc Protein, Recombinant
Endoglin/CD105	Human	Endoglin/CD105/Fc Protein, Recombinant
TGFBR2	Human	TGFBR2/Fc Protein, Recombinant
Decorin	Human	Decorin/Fc Protein, Recombinant

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
TGF-beta 2	Human	Homo sapiens TGF-beta2 transcript variant 2 cDNA Clone(NM_003238.2)
TGF-beta 3	Human	Homo sapiens TGF-beta 3 cDNA Clone(NM_003239.2)
ALK-1/ACVRL1	Human	Homo sapiens ALK-1/ACVRL1 transcript variant 1 cDNA Clone(NM_000020.2)
ALK-7	Human	Homo sapiens ALK-7 cDNA Clone(NM_145259.2)
Cripto/TDGF1	Human	Homo sapiens Cripto/TDGF1 cDNA Clone(NM_003212.2)
Endoglin/CD105	Human	Homo sapiens Endoglin/CD105 transcript variant 1 cDNA Clone(NM_001114753.1)
TGFBR1/ALK-5	Human	Homo sapiens TGFBR1/ALK-5 cDNA Clone(NM_004612.2)
TGFBR2	Human	Homo sapiens TGFBR2 transcript variant 2 cDNA Clone(NM_003242.5)
BAMBI/NMA	Human	Homo sapiens BAMBI/NMA cDNA Clone(NM_012342.2)
Smad1	Human	Homo sapiens Smad1 cDNA Clone(NM_001003688.1)
Smad2	Human	Homo sapiens Smad2 transcript variant 2 cDNA Clone(NM_001003652.2)
Smad3	Human	Homo sapiens Smad3 cDNA Clone(NM_005902.3)
Smad5	Human	Homo sapiens Smad5 transcript variant 3 cDNA Clone(NM_001001420.1)

TGF-beta 1 Background

TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.

TGF-beta 1 Related Studies

1. Ghadami M, et al. (2000) Genetic Mapping of the Camurati-Engelmann Disease Locus to Chromosome 19q13.1-q13.3. Am J Hum. Genet. 66(1):143-7.
2. Letterio J, et al. (1998) Regulation of immune responses by TGF-beta. Annu Rev Immunol. 16:137-61.
3. Vaughn SP, et al. (2000) Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region. Genomics. 66(1):119-21.
4. Assoian R, et al. (1983) Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem. 258(11):7155-60.