Anti-TGF beta 1 Antibody

Cat: 10804-MM03


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Anti-TGF beta 1 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-TGF beta 1 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human TGF beta 1
Recombinant Human TGF-beta1 protein (Catalog#10804-HNAH)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TGF-beta1 / TGFB1 (rh TGF-beta1; Catalog#10804-HNAH; Ala 279-Ser 390; NP_000651.3). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography .
Monoclonal Mouse IgG1 Clone #1G9H11G3
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TGF beta 1 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 5-20 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TGF beta 1 Antibody (Mouse Monoclonal antibody) Images
Human TGF-beta 1/TGFB1 Western blot (WB) 13281
Anti-TGF beta 1 Antibody Alternative Names
Anti-CED Antibody;Anti-DPD1 Antibody;Anti-LAP Antibody;Anti-TGF-beta 1 Antibody;Anti-TGFB Antibody;Anti-TGFbeta Antibody
TGF beta 1 Background Information

TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
transforming growth factor, beta 1
Research Areas
  • Ghadami M, et al. (2000) Genetic Mapping of the Camurati-Engelmann Disease Locus to Chromosome 19q13.1-q13.3. Am J Hum. Genet. 66(1):143-7.
  • Letterio J, et al. (1998) Regulation of immune responses by TGF-beta. Annu Rev Immunol. 16:137-61.
  • Vaughn SP, et al. (2000) Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region. Genomics. 66(1):119-21.
  • Assoian R, et al. (1983) Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem. 258(11):7155-60.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TGF beta 1 Antibody Rabbit Polyclonal ELISA 90294-T16
    Anti-TGF beta 1 Antibody Rabbit Polyclonal WB,ELISA,IP 70087-T52
    Anti-TGF beta 1 Antibody Rabbit Polyclonal ELISA 90294-RP01
    Anti-TGF beta 1 Antibody Rabbit Polyclonal WB,ELISA 50698-T48
    Anti-TGF beta 1 Antibody Rabbit Polyclonal ELISA 50698-RP01
    Anti-TGF beta 1 Antibody Rabbit Polyclonal ELISA 10804-RP02
    Anti-TGF beta 1 Antibody Rabbit Polyclonal ELISA 10804-T16
    Anti-TGF beta 1 Antibody Rabbit Monoclonal ELISA 10804-R016
    Anti-TGF beta 1 Antibody Rabbit Polyclonal ELISA 10804-RP01
    Anti-TGF beta 1 Antibody Mouse Monoclonal ELISA 10804-MM06
    Anti-TGF beta 1 Antibody Rabbit Polyclonal WB,ELISA 10804-T48
    Anti-TGF beta 1 Antibody Mouse Monoclonal ELISA(Cap) 10804-MM08
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