Quick Order

Text Size:AAA

TGF-beta 1 / TGFB1 Antibody, Rabbit PAb

DatasheetReviewsRelated ProductsProtocols
Human TGF-beta 1/TGFB1 Antibody Product Information
Immunogen:Recombinant Human TGF-beta1 protein (Catalog#10804-HNAH)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human TGFB1 / TGF-beta1 (rh TGF-beta1; Catalog#10804-HNAH; NP_000651.3; Ala 279-Ser 390). Total IgG was purified by Protein A affinity chromatography.
Human TGF-beta 1/TGFB1 Antibody Usage Guide
Specificity:Human TGF-beta1 / TGFB1
Application:ELISA

ELISA: 0.5-1.0 μg/mL

This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human TGF-beta1. The detection limit for Human TGF-beta 1 is 0.0049 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other TGF-beta 1/TGFB1 Antibody Products
Reactivity: Human  
Application: ELISA  
    10804-RP02-200
    10804-RP02-50
    10804-RP02-100
    200 µg 
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: WB  
    • Slide 1
    10804-MM03-200
    10804-MM03-50
    10804-MM03-100
    200 µg 
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10804-MM06-200
      10804-MM06-50
      10804-MM06-100
      200 µg 
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10804-R016-50
        10804-R016-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  WB  IP  
        • Slide 1
        • Slide 1
        10804-T52-100
        10804-T52-200
        10804-T52-50
        100 µg 
        200 µg 
        50 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  
          50698-RP01-100
          50698-RP01-200
          50698-RP01-400
          100 µg 
          200 µg 
           
          Add to Cart
          Reactivity: Cynomolgus  
          Application: ELISA  
            90294-RP01-100
            90294-RP01-200
            90294-RP01-400
            100 µg 
            200 µg 
             
            Add to Cart
            Reactivity: Cynomolgus  
            Application: ELISA  
              90294-T16-100
              90294-T16-50
              90294-T16-200
              100 µg 
              50 µg 
              200 µg 
              Add to Cart
              Reactivity: Canine  
              Application: ELISA  WB  IP  
              • Slide 1
              • Slide 1
              70087-T52-200
              70087-T52-100
              70087-T52-50
              200 µg 
              100 µg 
              50 µg 
              Add to Cart
              TGF-beta 1/TGFB1 Background

              TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.

              Human TGF-beta 1/TGFB1 References
            • Ghadami M, et al. (2000) Genetic Mapping of the Camurati-Engelmann Disease Locus to Chromosome 19q13.1-q13.3. Am J Hum. Genet. 66(1):143-7.
            • Letterio J, et al. (1998) Regulation of immune responses by TGF-beta. Annu Rev Immunol. 16:137-61.
            • Vaughn SP, et al. (2000) Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region. Genomics. 66(1):119-21.
            • Assoian R, et al. (1983) Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem. 258(11):7155-60.
            • Product nameProduct name
              Size / Price
              Catalog: 10804-RP01-400
              List Price: 
              Price:      (You Save: )
              All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
              Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"