TFPI2

Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotein consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. TFPI2 inhibits plasmin-dependent activation of several metalloproteinases. TFPI2 is highly abundant in the full-term placenta and widely expressed in various adult human tissues, such as the liver, skeletal muscle, heart, kidney, and pancreas. The expression of TFPI2 in tumors is inversely related to an increasing degree of malignancy, which may suggest a role for TFPI2 in the maintenance of tumor stability and inhibition of the growth of neoplasms. TFPI2 inhibits the tissue factor/factor VIIa (TF/VIIa) complex and a wide variety of serine proteinases including plasmin, plasma kallikrein, factor XIa, trypsin, and chymotrypsin. TFPI2 is involved in regulating pericellular proteases implicated in a variety of physiologic and pathologic processes including cancer cell invasion, vascular inflammation, and atherosclerosis. TFPI2 has also been shown to induce apoptosis and inhibit angiogenesis, which may contribute significantly to tumor growth inhibition.

TFPI2 Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>TFPI2

Immunology>>Innate Immunity>>Coagulation>>TFPI2

Cardiovascular>>Coagulation>>TFPI2

TFPI2 Alternative Names

TFPI2, TFPI-2, PP5, REF1, FLJ21164 [Homo sapiens] 

Tfpi2, PP5/TFPI-2, AV000670 [Mus musculus]

Summaries for TFPI2

Wikipedia summary for TFPI2:

Tissue factor pathway inhibitor 2 is a protein that in humans is encoded by the TFPI2 gene.

Human TFPI2 Protein General Information

 

• Protein names: Tissue factor pathway inhibitor 2
  Short name=TFPI2
• Sequence length: 235 AA.
• Domain: This inhibitor contains three inhibitory domains.
• Sequence similarities: Contains 3 BPTI/Kunitz inhibitor domains.
• Subcellular location: Secreted.
• Tissue specificity: Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.

General information above from UniProt

Function for TFPI2 Protein

UniProtKB:

TFPI2 may play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. TFPI2 has no effect on thrombin.

Genatlas:

• TFPI2 inhibits strongly a wide variety of serine proteinases (trypsin, plasmin, factor XI and MMPs)
• TFPI2 plays a major role in cell migration and tumor invasion
• TFPI2 is serine proteinase inhibitor that induces caspase-mediated apoptosis when offered to a variety of tumor cells
• TFPI2 is critical for the regulation of extracellular matrix remodeling and atherosclerotic plaque stability
• TFPI2 is kunitz-type serine protease inhibitor, tumor suppressor gene in several types of cancer, including glioma

Homology for human TFPI2

• homolog to rattus Tfpi2 (56.58 pc)
• homolog to murine Tfpi2 (57.48 pc)