Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotein consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. TFPI2 inhibits plasmin-dependent activation of several metalloproteinases. TFPI2 is highly abundant in the full-term placenta and widely expressed in various adult human tissues, such as the liver, skeletal muscle, heart, kidney, and pancreas. The expression of TFPI2 in tumors is inversely related to an increasing degree of malignancy, which may suggest a role for TFPI2 in the maintenance of tumor stability and inhibition of the growth of neoplasms. TFPI2 inhibits the tissue factor/factor VIIa (TF/VIIa) complex and a wide variety of serine proteinases including plasmin, plasma kallikrein, factor XIa, trypsin, and chymotrypsin. TFPI2 is involved in regulating pericellular proteases implicated in a variety of physiologic and pathologic processes including cancer cell invasion, vascular inflammation, and atherosclerosis. TFPI2 has also been shown to induce apoptosis and inhibit angiogenesis, which may contribute significantly to tumor growth inhibition.
- Human TFPI2 Protein, Recombinant, Cat NO:10545-H08H
- Mouse TFPI2 / PP5 Protein, Recombinant, Cat NO:51002-M02H
- Mouse TFPI2 Protein, Recombinant, Cat NO:51002-M08H
- Anti-Human TFPI2 Mouse Monoclonal Antibody, Cat NO:10545-MM04
- Anti-Human TFPI2 Rabbit Polyclonal Antibody, Cat NO:10545-RP01
- Anti-Human TFPI2 Rabbit Polyclonal Antibody (Antigen Affinity Purified), Cat NO:10545-RP02
TFPI2 ELISA Pair sets
TFPI2 cDNA Clones
- Homo sapiens TFPI2 cDNA Clone(NM_006528.2), Cat NO:HG10545-M
- Mouse TFPI2 Gene cDNA Clone / ORF Clone, Cat NO:MG51002-G
TFPI2, TFPI-2, PP5, REF1, FLJ21164 [Homo sapiens]
Tfpi2, PP5/TFPI-2, AV000670 [Mus musculus]
Wikipedia summary for TFPI2:
Tissue factor pathway inhibitor 2 is a protein that in humans is encoded by the TFPI2 gene.
Tissue factor pathway inhibitor 2
This inhibitor contains three inhibitory domains.
Contains 3 BPTI/Kunitz inhibitor domains.
Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.
General information above from UniProt
TFPI2 may play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. TFPI2 has no effect on thrombin.
- TFPI2 inhibits strongly a wide variety of serine proteinases (trypsin, plasmin, factor XI and MMPs)
- TFPI2 plays a major role in cell migration and tumor invasion
- TFPI2 is serine proteinase inhibitor that induces caspase-mediated apoptosis when offered to a variety of tumor cells
- TFPI2 is critical for the regulation of extracellular matrix remodeling and atherosclerotic plaque stability
- TFPI2 is kunitz-type serine protease inhibitor, tumor suppressor gene in several types of cancer, including glioma
- homolog to rattus Tfpi2 (56.58 pc)
- homolog to murine Tfpi2 (57.48 pc)