TFPI2 Protein & Antibody

Tissue Factor Pathway Inhibitor 2

TFPI2 Products

TFPI2 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
TFPI2	Human	TFPI2 Protein, Recombinant	10545-H08H
TFPI2	Mouse	TFPI2 / PP5 Protein, Recombinant	51002-M02H
TFPI2	Mouse	TFPI2 Protein, Recombinant	51002-M08H

10545-H08H : IC₅₀ value  < 2 nM, Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 ( Anaspec, Catalog#27114 )

TFPI2 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human TFPI2	ELISA	Mouse Monoclonal Antibody	10545-MM04
Human TFPI2	WB, ELISA	Rabbit Polyclonal Antibody	10545-RP01
Human TFPI2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10545-RP02

TFPI2 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
TFPI2	Human	Homo sapiens TFPI2 cDNA Clone(NM_006528.2)	HG10545-M
TFPI2	Mouse	Mouse TFPI2 Gene cDNA Clone / ORF Clone	MG51002-G

TFPI2 Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>TFPI2

Immunology>>Innate Immunity>>Coagulation>>TFPI2

Cardiovascular>>Coagulation>>TFPI2

TFPI2 Alternative Names

TFPI2, TFPI-2, PP5, REF1, FLJ21164 [Homo sapiens] 

Tfpi2, PP5/TFPI-2, AV000670 [Mus musculus]

TFPI2 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
TFPI	Human	TFPI Protein, Recombinant
TFPI	Mouse	TFPI Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human TFPI	WB, ELISA	Mouse Monoclonal Antibody
Human TFPI	ELISA	Rabbit Monoclonal Antibody
Human TFPI	WB	Rabbit Monoclonal Antibody
Human TFPI	WB, ELISA	Rabbit Polyclonal Antibody
Human TFPI	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Mouse TFPI	WB, ELISA	Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
TFPI	Human	Homo sapiens TFPI cDNA Clone
TFPI	Mouse	Mus musculus TFPI cDNA Clone

TFPI2 Background

Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotein consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. TFPI2 inhibits plasmin-dependent activation of several metalloproteinases. TFPI2 is highly abundant in the full-term placenta and widely expressed in various adult human tissues, such as the liver, skeletal muscle, heart, kidney, and pancreas. The expression of TFPI2 in tumors is inversely related to an increasing degree of malignancy, which may suggest a role for TFPI2 in the maintenance of tumor stability and inhibition of the growth of neoplasms. TFPI2 inhibits the tissue factor/factor VIIa (TF/VIIa) complex and a wide variety of serine proteinases including plasmin, plasma kallikrein, factor XIa, trypsin, and chymotrypsin. TFPI2 is involved in regulating pericellular proteases implicated in a variety of physiologic and pathologic processes including cancer cell invasion, vascular inflammation, and atherosclerosis. TFPI2 has also been shown to induce apoptosis and inhibit angiogenesis, which may contribute significantly to tumor growth inhibition.

TFPI2 Related Studies

1. Peerschke EI, et al. (2004) Tissue factor pathway inhibitor-2 (TFPI-2) recognizes the complement and kininogen binding protein gC1qR/p33 (gC1qR): implications for vascular inflammation. Thromb Haemost. 92(4): 811-9.
2. Rollin J, et al. (2005) Expression and methylation status of tissue factor pathway inhibitor-2 gene in non-small-cell lung cancer. Br J Cancer. 92(4): 775-83.
3. Chand HS, et al. (2005) Structure, function and biology of tissue factor pathway inhibitor-2. Thromb Haemost. 94(6): 1122-30.
4. Sierko E, et al. (2007) The role of tissue factor pathway inhibitor-2 in cancer biology. Semin Thromb Hemost. 33(7): 653-9.