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TFPI Protein, Antibody, ELISA Kit, cDNA Clone

Mouse TFPI  Protein

Description: Active
Expression host: Human Cells
  • Slide 1
50131-M08H-10
50131-M08H-20
10 µg / $170
20 µg / $290
Add to Cart

Human TFPI  Protein

Description: Active
Expression host: Human Cells
  • Slide 1
10564-H08H-10
10564-H08H-20
10 µg / $170
20 µg / $290
Add to Cart

TFPI Related Areas

TFPI Related Pathways

TFPI Related Product

    TFPI Background

    Gene Summary: TFPI gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of TFPI gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    Domain: This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa.
    Subcellular location: Isoform Alpha: Secreted.
    Isoform Beta: Microsome membrane; Lipid- anchor, GPI-anchor.
    Tissue specificity: Mostly in endothelial cells.
    Post-translational: O-glycosylated.
    Sequence similarities: Contains 3 BPTI/Kunitz inhibitor domains.
    General information above from UniProt

    Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is emphasized by how its activity is modulated in human disease. In a factor (F) Xa-dependent feedback system, TFPI binds directly and inhibits the TF-FVII/FVIIa complex. Normally, TFPI exists in plasma both as a full-length molecule and as variably carboxy-terminal truncated forms. TFPI also circulates in complex with plasma lipoproteins. The levels and the dual inhibitor effect of TFPI on FXa and TF-FVII/FVIIa complex offers insight into the mechanisms of various pathological conditions triggered by TF. TFPI may play an important role in modulating TF-induced thrombogenesis and it may also provide a unique therapeutic approach for prophylaxis and/or treatment of various diseases. In addition, Studies have shown that TFPI exhibits antiangiogenic and antimetastatic effects in vitro and in vivo. In animal models of experimental metastasis, both circulating and tumor cell-associated TFPI are shown to significantly reduce tumor cell-induced coagulation activation and lung metastasis. Heparins and heparin derivatives, which induce the release of TFPI from the vascular endothelium, also exhibit antitumor effects, and TFPI may contribute significantly to those effects.

    TFPI Altermative Names