Anti-TFPI Antibody

Cat: 10564-MM01
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All TFPI Reagents
Anti-TFPI Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-TFPI Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human TFPI
No cross-reactivity in ELISA with Mouse TFPI / LACI / EPI Human TFPI2 / PP5 Human Vitronectin / VTN
Immunogen
Recombinant Human TFPI Protein (Catalog#10564-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TFPI / LACI (rh TFPI; Catalog#10564-H08H; NP_006278.1; Met 1-Lys 282). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG2b Clone #6D1A8E7
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TFPI Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TFPI Antibody Alternative Names
Anti-EPI Antibody;Anti-LACI Antibody;Anti-TFI Antibody;Anti-TFPI1 Antibody
TFPI Background Information

Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is emphasized by how its activity is modulated in human disease. In a factor (F) Xa-dependent feedback system, TFPI binds directly and inhibits the TF-FVII/FVIIa complex. Normally, TFPI exists in plasma both as a full-length molecule and as variably carboxy-terminal truncated forms. TFPI also circulates in complex with plasma lipoproteins. The levels and the dual inhibitor effect of TFPI on FXa and TF-FVII/FVIIa complex offers insight into the mechanisms of various pathological conditions triggered by TF. TFPI may play an important role in modulating TF-induced thrombogenesis and it may also provide a unique therapeutic approach for prophylaxis and/or treatment of various diseases. In addition, Studies have shown that TFPI exhibits antiangiogenic and antimetastatic effects in vitro and in vivo. In animal models of experimental metastasis, both circulating and tumor cell-associated TFPI are shown to significantly reduce tumor cell-induced coagulation activation and lung metastasis.

Full Name
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
References
  • Lwaleed BA, et al. (2006) Tissue factor pathway inhibitor: structure, biology and involvement in disease. J Pathol. 208(3): 327-39.
  • Amirkhosravi A, et al. (2007) The role of tissue factor pathway inhibitor in tumor growth and metastasis. Semin Thromb Hemost. 33(7): 643-52.
  • Maroney SA, et al. (2008) Expression of tissue factor pathway inhibitor by endothelial cells and platelets. Transfus Apher Sci. 38(1): 9-14.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-TFPI Antibody Rabbit Monoclonal ELISA(Det) 50131-R103
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    Anti-TFPI Antibody Rabbit Monoclonal ELISA(Det),IHC-P,ICC/IF,IF 10564-R401
    Anti-TFPI Antibody Rabbit Polyclonal ELISA 10564-RP02
    Anti-TFPI Antibody Mouse Monoclonal ELISA(Cap) 10564-MM02
    Anti-TFPI Antibody Rabbit Monoclonal ELISA 10564-R003
    Anti-TFPI Antibody Rabbit Monoclonal WB,IP 10564-R006
    Anti-TFPI Antibody Rabbit Polyclonal ELISA 10564-RP01
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